Propranolol elicits cutaneous analgesia against skin nociceptive stimuli in rats

Yu Wen Chen, Chin Chen Chu, Yu Chung Chen, Ching Hsia Hung, Jhi Joung Wang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this study was to investigate the cutaneous analgesic effect of propranolol and compare with a local anesthetic lidocaine. The potencies and equipotent doses were determined for infiltrative cutaneous analgesia on the rat back by determination of dose-response curves for propranolol and lidocaine. Propranolol as well as lidocaine elicited dose-dependent cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potency was propranolol (10.3 [8.9-11.9]μmolkg-1)>lidocaine (25.8 [24.3-27.8]μmolkg-1) (P<0.01). On equianalgesic doses (ED25, ED50, ED75), propranolol produced longer action of infiltrative cutaneous analgesia than lidocaine (P<0.01). Coadministration of lidocaine (25.8μmolkg-1) and propranolol (1.7μmolkg-1) exhibited greater blockade and duration than lidocaine (25.8μmolkg-1) or propranolol (1.7μmolkg-1) alone. Propranolol displayed more potent and longer duration of action than lidocaine at producing cutaneous analgesia. Furthermore, propranolol may prove useful as an adjuvant for lidocaine in producing cutaneous analgesia.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalNeuroscience Letters
Volume524
Issue number2
DOIs
Publication statusPublished - 2012 Aug 30

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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