Prospective randomized study of efficacy of 1-day versus 3-day antibiotic prophylaxis for preventing surgical site infection after coronary artery bypass graft

Mei Hsin Lin, Sung Ching Pan, Jiun Ling Wang, Ron Bin Hsu, Fei Lin Lin Wu, Yee Chun Chen, Fang Yue Lin, Shan Chwen Chang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background/Purpose: Despite general recommendation of short-course antibiotic prophylaxis, prolonged antibiotic use is still commonly reported in clinical settings. This study compared the efficacy of 1-day versus 3-day antibiotic prophylaxis in preventing surgical site infection (SSI) in patients undergoing coronary artery bypass graft (CABG). Methods: This prospective, randomized control study was performed in a tertiary-care medical center from June 2002 to April 2004. Patients underwent non-emergency CABG and were randomized into two groups receiving either 1 day or 3 days cefazolin prophylaxis. The SSI rates were compared between the two groups. Results: During the study period, 231 patients were enrolled, 120 in the 1-day group and 111 in the 3-day group. Twenty-two episodes of SSI were observed within 1 month after operation: 13 (10.8%) in the 1-day group and nine (8.1%) in the 3-day group (odds ratio: 1.37; 95% confidence interval: 0.56-3.33; p = 0.48). By logistic regression analysis, 1-day prophylaxis with cefazolin was not associated with higher risk of SSI (adjusted odds ratio: 0.91; 95% confidence interval: 0.32-2.56; p = 0.85). Conclusion: Antibiotic prophylaxis for 1 day in CABG surgery was associated with similar rates of postoperative infection compared with antibiotic prophylaxis of 3 days.

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalJournal of the Formosan Medical Association
Volume110
Issue number10
DOIs
Publication statusPublished - 2011 Oct

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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