Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells

Ying Chang Hsueh, Jasmine M.F. Wu, Chun Keung Yu, Kenneth K. Wu, Patrick C.H. Hsieh

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Although self-renewal ability of adult mammalian heart has been reported, few pharmacological treatments are known to promote cardiomyocyte regeneration after injury. In this study, we demonstrate that the critical period of stem/progenitor cell-mediated cardiomyocyte replenishment is initiated within 7 days and saturates on day 10 post-infarction. Moreover, blocking the inflammatory reaction with COX-2 inhibitors may also reduce the capability of endogenous stem/progenitor cells to repopulate lost cells. Injection of the COX-2 product PGE2 enhances cardiomyocyte replenishment in young mice and recovers cell renewal through attenuating TGF-β1 signaling in aged mice. Further analyses suggest that cardiac stem cells are PGE2-responsive and that PGE2 may regulate stem cell activity directly through the EP2 receptor or indirectly by modulating its micro-environment in vivo. Our findings provide evidence that PGE2 holds great potential for cardiac regeneration.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalEMBO Molecular Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - 2014 Apr

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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