TY - JOUR
T1 - Prostaglandin E2
T2 - The master of endometriosis?
AU - Wu, Meng Hsing
AU - Lu, Chun Wun
AU - Chuang, Pei Chin
AU - Tsai, Shaw Jenq
N1 - Funding Information:
This work was supported by grants from National Science Council of Taiwan, Republic of China (NSC95-2320-B-006-047-MY3 and 97-2314-B-006-020-MY3).
PY - 2010/6
Y1 - 2010/6
N2 - Endometriosis is the primary cause of infertility in women, with a prevalence rate ranging from 5% to 10%. Women with endometriosis suffer from symptoms such as chronic pelvic pain, dysmenorrhea and dyspareunia, which significantly reduce the quality of life. Endometriosis is a polygenic disease with a complex, multifactorial etiology. The mechanism responsible for the initiation and development of this disease remains largely unknown. Prostaglandin E2 (PGE2), a versatile eicosanoid that exerts numerous physiological and pathological functions, has been implicated to play critical roles in the development of endometriosis. A growing body of evidence demonstrates that PGE2 regulates many pathophysiological processes including cell proliferation, antiapoptosis, immune suppression and angiogenesis during the development of endometriosis. This review focuses on recent advances in cellular and molecular mechanisms triggered by PGE 2 that contribute to the pathological processes of endometriosis.
AB - Endometriosis is the primary cause of infertility in women, with a prevalence rate ranging from 5% to 10%. Women with endometriosis suffer from symptoms such as chronic pelvic pain, dysmenorrhea and dyspareunia, which significantly reduce the quality of life. Endometriosis is a polygenic disease with a complex, multifactorial etiology. The mechanism responsible for the initiation and development of this disease remains largely unknown. Prostaglandin E2 (PGE2), a versatile eicosanoid that exerts numerous physiological and pathological functions, has been implicated to play critical roles in the development of endometriosis. A growing body of evidence demonstrates that PGE2 regulates many pathophysiological processes including cell proliferation, antiapoptosis, immune suppression and angiogenesis during the development of endometriosis. This review focuses on recent advances in cellular and molecular mechanisms triggered by PGE 2 that contribute to the pathological processes of endometriosis.
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U2 - 10.1258/ebm.2010.009321
DO - 10.1258/ebm.2010.009321
M3 - Short survey
C2 - 20511671
AN - SCOPUS:77953224473
SN - 1535-3702
VL - 235
SP - 668
EP - 677
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 6
ER -