Protective effect of daily sesame oil supplement on gentamicin-induced renal injury in rats

Dur Zong Hsu, Chuan Teng Liu, Ya Hui Li, Pei Yi Chu, Ming-Yi Liu

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Gentamicin, an aminoglycoside antibiotic, is widely used in the treatment of Gram-negative infections; however, dose-limiting nephrotoxicity restricts its optimal use. We investigated the effect of a daily sesame oil supplement on oxidative-stress-associated renal injury induced by a single daily dose of gentamicin in rats. Renal injury was induced by a single subcutaneous daily dose of gentamicin (100 mg kg-1 d-1 for 7 days), and then the effects of oral sesame oil (0.25, 0.5, and 1 mL kg-1 d-1 for 7 days) on renal injury, oxidative stress, hydroxyl radical, superoxide anion, and NO were assessed after treatment. Sesame oil inhibited gentamicin-induced renal injury, lipid peroxidation, hydroxyl radical, and superoxide anion, as well as NO production. In addition, sesame oil inhibited xanthine oxidase activity and inducible NOS expression in gentamicin-challenged rats. We hypothesize that a daily sesame oil supplement attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalShock
Volume33
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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