Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats

Pei Yi Chu, Se Ping Chien, Dur Zong Hsu, Ming-Yi Liu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-α, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-α, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-α, nitrite, inducible nitric oxide synthase expression, and nuclear factor-κB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.

Original languageEnglish
Pages (from-to)1821-1826
Number of pages6
JournalFood and Chemical Toxicology
Volume48
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Lung Injury
lipopolysaccharides
protective effect
Lipopolysaccharides
Rats
tumor necrosis factors
Nitrites
inflammation
lungs
nitrites
Lung
Tumor Necrosis Factor-alpha
rats
Alveolar Macrophages
Nitric Oxide Synthase Type II
Pneumonia
macrophages
Bronchoalveolar Lavage Fluid
edema
Edema

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

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abstract = "We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-α, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-α, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-α, nitrite, inducible nitric oxide synthase expression, and nuclear factor-κB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.",
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Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats. / Chu, Pei Yi; Chien, Se Ping; Hsu, Dur Zong; Liu, Ming-Yi.

In: Food and Chemical Toxicology, Vol. 48, No. 7, 01.07.2010, p. 1821-1826.

Research output: Contribution to journalArticle

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