TY - JOUR
T1 - Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats
AU - Chu, Pei Yi
AU - Chien, Se Ping
AU - Hsu, Dur Zong
AU - Liu, Ming Yie
N1 - Funding Information:
This research was supported by Grants DOH92-TD-1009 from the Taiwan Department of Health and NSC 96-2628-B-006-038-MY3 and NSC 98-2312-B-006-002-MY3 from the National Science Council, Taiwan .
PY - 2010/7
Y1 - 2010/7
N2 - We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-α, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-α, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-α, nitrite, inducible nitric oxide synthase expression, and nuclear factor-κB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.
AB - We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-α, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-α, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-α, nitrite, inducible nitric oxide synthase expression, and nuclear factor-κB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.
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U2 - 10.1016/j.fct.2010.04.014
DO - 10.1016/j.fct.2010.04.014
M3 - Article
C2 - 20398721
AN - SCOPUS:77953535121
SN - 0278-6915
VL - 48
SP - 1821
EP - 1826
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
IS - 7
ER -