Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells

Pin Pin Lin, Ming Hui Yang, Pao Chi Liao, Hsin Yi Wu, Louis W. Chang, Hui Ti Tsai, Yu Chang Tyan

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Trans, trans-2,4-decadienal (tt-DDE), a specific type of dienaldehyde, is abundant in heated oils or cooking oil fumes. Ingestion of heated oils and exposure to cooking oil fumes has been suggested to have a great health impact in a variety of organs, including the lungs. Previous studies have demonstrated that acute exposures to high doses of tt-DDE have induced oxidative stress, genotoxicity, and cytotoxicity in human lung cells. The objective in utilizing proteomic techniques of this study was to identify protein biomarkers associated with tt-DDE-induced oxidative stress and cytotoxicity in human bronchial epithelial cells BEAS-2B. Experimental results suggested that DJ-1 and cofilin proteins were protein biomarkers for tt-DDE-induced cytotoxicity and oxidative stress in lung cells. DJ-1 was especially an early biomarker for tt-DDE exposure.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume376
Issue number3
DOIs
Publication statusPublished - 2008 Nov 21

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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