Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells

Pin Pin Lin; Ming Hui Yang; Pao Chi Liao; Hsin Yi Wu; Louis W. Chang; Hui Ti Tsai; Yu Chang Tyan

doi:10.1016/j.bbrc.2008.09.020

Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells

Pin Pin Lin, Ming Hui Yang, Pao Chi Liao, Hsin Yi Wu, Louis W. Chang, Hui Ti Tsai, Yu Chang Tyan

Department of Environmental and Occupational Health

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Trans, trans-2,4-decadienal (tt-DDE), a specific type of dienaldehyde, is abundant in heated oils or cooking oil fumes. Ingestion of heated oils and exposure to cooking oil fumes has been suggested to have a great health impact in a variety of organs, including the lungs. Previous studies have demonstrated that acute exposures to high doses of tt-DDE have induced oxidative stress, genotoxicity, and cytotoxicity in human lung cells. The objective in utilizing proteomic techniques of this study was to identify protein biomarkers associated with tt-DDE-induced oxidative stress and cytotoxicity in human bronchial epithelial cells BEAS-2B. Experimental results suggested that DJ-1 and cofilin proteins were protein biomarkers for tt-DDE-induced cytotoxicity and oxidative stress in lung cells. DJ-1 was especially an early biomarker for tt-DDE exposure.

Original language	English
Pages (from-to)	519-524
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	376
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2008.09.020
Publication status	Published - 2008 Nov 21

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells",

abstract = "Trans, trans-2,4-decadienal (tt-DDE), a specific type of dienaldehyde, is abundant in heated oils or cooking oil fumes. Ingestion of heated oils and exposure to cooking oil fumes has been suggested to have a great health impact in a variety of organs, including the lungs. Previous studies have demonstrated that acute exposures to high doses of tt-DDE have induced oxidative stress, genotoxicity, and cytotoxicity in human lung cells. The objective in utilizing proteomic techniques of this study was to identify protein biomarkers associated with tt-DDE-induced oxidative stress and cytotoxicity in human bronchial epithelial cells BEAS-2B. Experimental results suggested that DJ-1 and cofilin proteins were protein biomarkers for tt-DDE-induced cytotoxicity and oxidative stress in lung cells. DJ-1 was especially an early biomarker for tt-DDE exposure.",

author = "Lin, {Pin Pin} and Yang, {Ming Hui} and Liao, {Pao Chi} and Wu, {Hsin Yi} and Chang, {Louis W.} and Tsai, {Hui Ti} and Tyan, {Yu Chang}",

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T1 - Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells

AU - Lin, Pin Pin

AU - Yang, Ming Hui

AU - Liao, Pao Chi

AU - Wu, Hsin Yi

AU - Chang, Louis W.

AU - Tsai, Hui Ti

AU - Tyan, Yu Chang

PY - 2008/11/21

Y1 - 2008/11/21

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AB - Trans, trans-2,4-decadienal (tt-DDE), a specific type of dienaldehyde, is abundant in heated oils or cooking oil fumes. Ingestion of heated oils and exposure to cooking oil fumes has been suggested to have a great health impact in a variety of organs, including the lungs. Previous studies have demonstrated that acute exposures to high doses of tt-DDE have induced oxidative stress, genotoxicity, and cytotoxicity in human lung cells. The objective in utilizing proteomic techniques of this study was to identify protein biomarkers associated with tt-DDE-induced oxidative stress and cytotoxicity in human bronchial epithelial cells BEAS-2B. Experimental results suggested that DJ-1 and cofilin proteins were protein biomarkers for tt-DDE-induced cytotoxicity and oxidative stress in lung cells. DJ-1 was especially an early biomarker for tt-DDE exposure.

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