Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Liu Chun Wang; Pei Yu Chiou; Ya Ping Hsu; Chin Lai Lee; Chih Hsuan Hung; Yi Hsuan Wu; Wen Jyun Wang; Gia Ling Hsieh; Ying Chi Chen; Li Chan Chang; Wen Pin Su; Divinah Manoharan; Min Chiao Liao; Suresh Thangudu; Wei Peng Li; Chia Hao Su; Hong Kang Tian; Chen Sheng Yeh

doi:10.1038/s41467-023-40470-z

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Liu Chun Wang, Pei Yu Chiou, Ya Ping Hsu, Chin Lai Lee, Chih Hsuan Hung, Yi Hsuan Wu, Wen Jyun Wang, Gia Ling Hsieh, Ying Chi Chen, Li Chan Chang, Wen Pin Su, Divinah Manoharan, Min Chiao Liao, Suresh Thangudu, Wei Peng Li, Chia Hao Su, Hong Kang Tian, Chen Sheng Yeh

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26 Citations (Scopus)

Abstract

Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H₂O₂ → ‧OH for tumoral therapy. Unfortunately, H₂O₂ is often taken from the limited endogenous supply of H₂O₂ in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H₂O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe³⁺-N ≡ C-Fe²⁺ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O₂, H₂O_2, and ‧OH from H₂O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

Original language	English
Article number	4709
Journal	Nature communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-40470-z
Publication status	Published - 2023 Dec

All Science Journal Classification (ASJC) codes

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-023-40470-z

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Wang, L. C., Chiou, P. Y., Hsu, Y. P., Lee, C. L., Hung, C. H., Wu, Y. H., Wang, W. J., Hsieh, G. L., Chen, Y. C., Chang, L. C., Su, W. P., Manoharan, D., Liao, M. C., Thangudu, S., Li, W. P., Su, C. H., Tian, H. K., & Yeh, C. S. (2023). Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments. Nature communications, 14(1), Article 4709. https://doi.org/10.1038/s41467-023-40470-z

@article{0150a9aba74845479026ece33f8bd09b,

title = "Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments",

abstract = "Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+-N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O2, H2O2, and ‧OH from H2O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.",

author = "Wang, {Liu Chun} and Chiou, {Pei Yu} and Hsu, {Ya Ping} and Lee, {Chin Lai} and Hung, {Chih Hsuan} and Wu, {Yi Hsuan} and Wang, {Wen Jyun} and Hsieh, {Gia Ling} and Chen, {Ying Chi} and Chang, {Li Chan} and Su, {Wen Pin} and Divinah Manoharan and Liao, {Min Chiao} and Suresh Thangudu and Li, {Wei Peng} and Su, {Chia Hao} and Tian, {Hong Kang} and Yeh, {Chen Sheng}",

note = "Funding Information: C.S. Yeh appreciates the financial support by the Ministry of Science and Technology, Taiwan (MOST109-2113-M-006-011-MY3). This research was also supported in part by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. Additional financially support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. W. P. Li appreciates the financial support by the National Science and Technology Council, Taiwan (NSTC 109-2113-M-037-017-MY3, NSTC 112-2320-B-037-035 and NSTC 112-2113-M-037-014-MY2), the Kaohsiung Medical University Research Foundation (KMU-Q111002) and the Yushan Young Scholar Program under the MOE, Taiwan. C. H. Su appreciates the financial support by the National Science and Technology Council, Taiwan (NSTC 111-2811-B-182-033-, 109-2314-B-182-082-MY3, and 112-2314-B-182-045-MY3), and the Chang Gung Medical Foundation, Taiwan (CMRPG8M0121-3 and CMRPD5N0011-3). H.K.T appreciates the financial support from the National Science and Technology Council of Taiwan (110-2222-E-006-014-MY3) and the National Center for High-performance Computing (NCHC) for providing computational and storage resources. Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2023",

month = dec,

doi = "10.1038/s41467-023-40470-z",

language = "English",

volume = "14",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Wang, LC, Chiou, PY, Hsu, YP, Lee, CL, Hung, CH, Wu, YH, Wang, WJ, Hsieh, GL, Chen, YC, Chang, LC, Su, WP , Manoharan, D, Liao, MC, Thangudu, S, Li, WP, Su, CH, Tian, HK & Yeh, CS 2023, 'Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments', Nature communications, vol. 14, no. 1, 4709. https://doi.org/10.1038/s41467-023-40470-z

TY - JOUR

T1 - Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

AU - Wang, Liu Chun

AU - Chiou, Pei Yu

AU - Hsu, Ya Ping

AU - Lee, Chin Lai

AU - Hung, Chih Hsuan

AU - Wu, Yi Hsuan

AU - Wang, Wen Jyun

AU - Hsieh, Gia Ling

AU - Chen, Ying Chi

AU - Chang, Li Chan

AU - Su, Wen Pin

AU - Manoharan, Divinah

AU - Liao, Min Chiao

AU - Thangudu, Suresh

AU - Li, Wei Peng

AU - Su, Chia Hao

AU - Tian, Hong Kang

AU - Yeh, Chen Sheng

N1 - Funding Information: C.S. Yeh appreciates the financial support by the Ministry of Science and Technology, Taiwan (MOST109-2113-M-006-011-MY3). This research was also supported in part by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. Additional financially support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. W. P. Li appreciates the financial support by the National Science and Technology Council, Taiwan (NSTC 109-2113-M-037-017-MY3, NSTC 112-2320-B-037-035 and NSTC 112-2113-M-037-014-MY2), the Kaohsiung Medical University Research Foundation (KMU-Q111002) and the Yushan Young Scholar Program under the MOE, Taiwan. C. H. Su appreciates the financial support by the National Science and Technology Council, Taiwan (NSTC 111-2811-B-182-033-, 109-2314-B-182-082-MY3, and 112-2314-B-182-045-MY3), and the Chang Gung Medical Foundation, Taiwan (CMRPG8M0121-3 and CMRPD5N0011-3). H.K.T appreciates the financial support from the National Science and Technology Council of Taiwan (110-2222-E-006-014-MY3) and the National Center for High-performance Computing (NCHC) for providing computational and storage resources. Publisher Copyright: © 2023, Springer Nature Limited.

PY - 2023/12

Y1 - 2023/12

N2 - Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+-N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O2, H2O2, and ‧OH from H2O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

AB - Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue (CFPB) nanoframes is presented to provide sustained, external energy-free self-supply of ‧OH from H2O to process CDT and/or photothermal therapy (PTT). Unexpectedly, the as-prepared CFPB nanocubes with no near-infrared (NIR) absorption is transformed into CFPB nanoframes with NIR absorption due to the increased Fe3+-N ≡ C-Fe2+ composition through the proposed proton-induced metal replacement reactions. Surprisingly, both the CFPB nanocubes and nanoframes provide for the self-supply of O2, H2O2, and ‧OH from H2O, with the nanoframe outperforming in the production of ‧OH. Simulation analysis indicates separated active sites in catalyzation of water oxidation, oxygen reduction, and Fenton-like reactions from CFPB. The liposome-covered CFPB nanoframes prepared for controllable water-driven CDT for male tumoral mice treatments.

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U2 - 10.1038/s41467-023-40470-z

DO - 10.1038/s41467-023-40470-z

M3 - Article

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AN - SCOPUS:85166599453

SN - 2041-1723

VL - 14

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 4709

ER -

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Abstract

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