Pterostilbene Protection and Bladder Cancer Cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traditional chemotherapy for advanced bladder cancer is toxic, not easily tolerated, and shows a low long-term survival rate in patients; hence, developing novel therapeutic agents for bladder cancer treatment is needed. Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, which is attributed to its unique structure. Recently, pterostilbene has been reported to induce cytotoxic and cytostatic effects in both sensitive and chemoresistant bladder cancer cells by inducing necrosis, cell cycle arrest, apoptosis, and autophagy through modulating various signaling pathways.This chapter elucidates the protective effects and the mechanisms of pterostilbene from the viewpoint of its pharmacokinetic, antioxidant, anti-inflammatory, and anticancer effects. Thus, pterostilbene functions as an efficient natural product in cancer prevention and treatment by modulating multiple targets in cancer cells, which may be also effective in the management of bladder cancer.

Original languageEnglish
Title of host publicationCancer
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages271-281
Number of pages11
ISBN (Print)9780124052055
DOIs
Publication statusPublished - 2014 Jan 1

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Urinary Bladder Neoplasms
Insurance Benefits
Antioxidants
Poisons
Autophagy
Cytostatic Agents
Cell Cycle Checkpoints
Biological Products
Neoplasms
Anti-Inflammatory Agents
Necrosis
Therapeutics
Survival Rate
Pharmacokinetics
Apoptosis
Drug Therapy
pterostilbene

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Medicine(all)

Cite this

Wang, Y-J., & Chen, R-J. (2014). Pterostilbene Protection and Bladder Cancer Cells. In Cancer: Oxidative Stress and Dietary Antioxidants (pp. 271-281). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405205-5.00027-1
Wang, Ying-Jan ; Chen, Rong-Jane. / Pterostilbene Protection and Bladder Cancer Cells. Cancer: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. pp. 271-281
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Wang, Y-J & Chen, R-J 2014, Pterostilbene Protection and Bladder Cancer Cells. in Cancer: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., pp. 271-281. https://doi.org/10.1016/B978-0-12-405205-5.00027-1

Pterostilbene Protection and Bladder Cancer Cells. / Wang, Ying-Jan; Chen, Rong-Jane.

Cancer: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. p. 271-281.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Traditional chemotherapy for advanced bladder cancer is toxic, not easily tolerated, and shows a low long-term survival rate in patients; hence, developing novel therapeutic agents for bladder cancer treatment is needed. Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, which is attributed to its unique structure. Recently, pterostilbene has been reported to induce cytotoxic and cytostatic effects in both sensitive and chemoresistant bladder cancer cells by inducing necrosis, cell cycle arrest, apoptosis, and autophagy through modulating various signaling pathways.This chapter elucidates the protective effects and the mechanisms of pterostilbene from the viewpoint of its pharmacokinetic, antioxidant, anti-inflammatory, and anticancer effects. Thus, pterostilbene functions as an efficient natural product in cancer prevention and treatment by modulating multiple targets in cancer cells, which may be also effective in the management of bladder cancer.

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Wang Y-J, Chen R-J. Pterostilbene Protection and Bladder Cancer Cells. In Cancer: Oxidative Stress and Dietary Antioxidants. Elsevier Inc. 2014. p. 271-281 https://doi.org/10.1016/B978-0-12-405205-5.00027-1