Traditional chemotherapy for advanced bladder cancer is toxic, not easily tolerated, and shows a low long-term survival rate in patients; hence, developing novel therapeutic agents for bladder cancer treatment is needed. Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, which is attributed to its unique structure. Recently, pterostilbene has been reported to induce cytotoxic and cytostatic effects in both sensitive and chemoresistant bladder cancer cells by inducing necrosis, cell cycle arrest, apoptosis, and autophagy through modulating various signaling pathways.This chapter elucidates the protective effects and the mechanisms of pterostilbene from the viewpoint of its pharmacokinetic, antioxidant, anti-inflammatory, and anticancer effects. Thus, pterostilbene functions as an efficient natural product in cancer prevention and treatment by modulating multiple targets in cancer cells, which may be also effective in the management of bladder cancer.
|Title of host publication||Cancer|
|Subtitle of host publication||Oxidative Stress and Dietary Antioxidants|
|Number of pages||11|
|Publication status||Published - 2014 Jan 1|
All Science Journal Classification (ASJC) codes