Pulmonary alveolar proteinosis with upper-lobe predominance in a non-smoking female

Research output: Contribution to journalArticle

Abstract

In this report, we describe an unusual manifestation of pulmonary alveolar proteinosis (PAP). The patient is a 43-year-old non-smoking female without underlying hematologic or auto-immune disorder. Her initial presentation included non-specific respiratory symptoms (exertional dyspnoea and cough), an unremarkable physical examination, a mild elevation in her serum level of lactate dehydrogenase, a mild impairment in the diffusion capacity for carbon monoxide but a normal spirometry, and multiple ground-glass opacities with a “crazy-paving” pattern predominantly in upper lung zones on her chest radiographic images. PAP was diagnosed histologically. PAP commonly occurs in males with smoking history, and tends to affect the lung parenchyma diffusely or, as in auto-immune PAP, lower lobes predominantly. Upper-lobe predominant PAP, particularly in a non-smoking female, is rare. This report would add PAP to the list of differential diagnosis for upper-lung ground-glass opacities. A review on the relevant literature is also included in the discussion.

Original languageEnglish
Article numbere00445
JournalRespirology Case Reports
Volume7
Issue number6
DOIs
Publication statusPublished - 2019 Aug 1

Fingerprint

Pulmonary Alveolar Proteinosis
Lung
Glass
Spirometry
Immune System Diseases
Carbon Monoxide
L-Lactate Dehydrogenase
Cough
Dyspnea
Physical Examination
Differential Diagnosis
Thorax
Smoking
History
Serum

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

@article{36488ba49eec4167bad736434e8cb7ea,
title = "Pulmonary alveolar proteinosis with upper-lobe predominance in a non-smoking female",
abstract = "In this report, we describe an unusual manifestation of pulmonary alveolar proteinosis (PAP). The patient is a 43-year-old non-smoking female without underlying hematologic or auto-immune disorder. Her initial presentation included non-specific respiratory symptoms (exertional dyspnoea and cough), an unremarkable physical examination, a mild elevation in her serum level of lactate dehydrogenase, a mild impairment in the diffusion capacity for carbon monoxide but a normal spirometry, and multiple ground-glass opacities with a “crazy-paving” pattern predominantly in upper lung zones on her chest radiographic images. PAP was diagnosed histologically. PAP commonly occurs in males with smoking history, and tends to affect the lung parenchyma diffusely or, as in auto-immune PAP, lower lobes predominantly. Upper-lobe predominant PAP, particularly in a non-smoking female, is rare. This report would add PAP to the list of differential diagnosis for upper-lung ground-glass opacities. A review on the relevant literature is also included in the discussion.",
author = "Er, {Hong Ping} and Chung-Ta Lee and Tang-Hsiu Huang",
year = "2019",
month = "8",
day = "1",
doi = "10.1002/rcr2.445",
language = "English",
volume = "7",
journal = "Respirology Case Reports",
issn = "2051-3380",
publisher = "Wiley-Blackwell",
number = "6",

}

Pulmonary alveolar proteinosis with upper-lobe predominance in a non-smoking female. / Er, Hong Ping; Lee, Chung-Ta; Huang, Tang-Hsiu.

In: Respirology Case Reports, Vol. 7, No. 6, e00445, 01.08.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pulmonary alveolar proteinosis with upper-lobe predominance in a non-smoking female

AU - Er, Hong Ping

AU - Lee, Chung-Ta

AU - Huang, Tang-Hsiu

PY - 2019/8/1

Y1 - 2019/8/1

N2 - In this report, we describe an unusual manifestation of pulmonary alveolar proteinosis (PAP). The patient is a 43-year-old non-smoking female without underlying hematologic or auto-immune disorder. Her initial presentation included non-specific respiratory symptoms (exertional dyspnoea and cough), an unremarkable physical examination, a mild elevation in her serum level of lactate dehydrogenase, a mild impairment in the diffusion capacity for carbon monoxide but a normal spirometry, and multiple ground-glass opacities with a “crazy-paving” pattern predominantly in upper lung zones on her chest radiographic images. PAP was diagnosed histologically. PAP commonly occurs in males with smoking history, and tends to affect the lung parenchyma diffusely or, as in auto-immune PAP, lower lobes predominantly. Upper-lobe predominant PAP, particularly in a non-smoking female, is rare. This report would add PAP to the list of differential diagnosis for upper-lung ground-glass opacities. A review on the relevant literature is also included in the discussion.

AB - In this report, we describe an unusual manifestation of pulmonary alveolar proteinosis (PAP). The patient is a 43-year-old non-smoking female without underlying hematologic or auto-immune disorder. Her initial presentation included non-specific respiratory symptoms (exertional dyspnoea and cough), an unremarkable physical examination, a mild elevation in her serum level of lactate dehydrogenase, a mild impairment in the diffusion capacity for carbon monoxide but a normal spirometry, and multiple ground-glass opacities with a “crazy-paving” pattern predominantly in upper lung zones on her chest radiographic images. PAP was diagnosed histologically. PAP commonly occurs in males with smoking history, and tends to affect the lung parenchyma diffusely or, as in auto-immune PAP, lower lobes predominantly. Upper-lobe predominant PAP, particularly in a non-smoking female, is rare. This report would add PAP to the list of differential diagnosis for upper-lung ground-glass opacities. A review on the relevant literature is also included in the discussion.

UR - http://www.scopus.com/inward/record.url?scp=85067644747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067644747&partnerID=8YFLogxK

U2 - 10.1002/rcr2.445

DO - 10.1002/rcr2.445

M3 - Article

AN - SCOPUS:85067644747

VL - 7

JO - Respirology Case Reports

JF - Respirology Case Reports

SN - 2051-3380

IS - 6

M1 - e00445

ER -