TY - JOUR
T1 - Quantifying passive muscle stiffness in children with and without cerebral palsy using ultrasound shear wave elastography
AU - Brandenburg, Joline E.
AU - Eby, Sarah F.
AU - Song, Pengfei
AU - Kingsley-Berg, Shirley
AU - Bamlet, William
AU - Sieck, Gary C.
AU - An, Kai Nan
N1 - Funding Information:
The authors thank the National Institutes of Health (grants KL2TR000136–07, K12HD00109, F30 AG044075), and the Mayo Clinic Department of Physical Medicine and Rehabilitation for supporting this research. In addition, this publication was made possible by CTSA Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health. The opinions expressed are those of the authors and do not necessarily express the opinions of the National Institutes of Health. Portions of this work were presented at the Association of Academic Physiatrists Annual Meeting, 16 to 20 February 2016 in Sacramento, CA, USA. The authors have stated that they had no interests which might be perceived as posing a conflict or bias.
Publisher Copyright:
© 2016 Mac Keith Press
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Aim: The aim of this study was to compare passive muscle stiffness in children with cerebral palsy (CP) and children with typical development using a novel ultrasound technique: ultrasound shear wave elastography (SWE). Method: We conducted a prospective study of 13 children with CP (six females and seven males, median age 5y 1mo [interquartile range 4y 4mo–7y 8mo]) and 13 children with typical development (six females and seven males, median age 5y 3mo [interquartile range 4y 4mo–9y 4mo]). Demographic information and physical exam measurements were obtained in addition to shear modulus measurements (passive muscle stiffness) of the lateral gastrocnemius muscle at 20° plantar flexion, 10° plantar flexion, and 0° plantar flexion using SWE. Results: Children with CP had significantly greater shear modulus measurements at all three foot positions (p<0.050). When the shear modulus values were normalized to the baseline value for each child, there was no significant difference between the two groups. Interpretation: Passive muscle stiffness, measured without the influence of spasticity, is greater in children with CP than in children with typical development when a muscle is at slack and at stretch. When shear modulus was normalized, the results indicate that muscle in children in both groups responds similarly to passive stretch. Further work includes evaluating effect of botulinum toxin on passive muscle properties.
AB - Aim: The aim of this study was to compare passive muscle stiffness in children with cerebral palsy (CP) and children with typical development using a novel ultrasound technique: ultrasound shear wave elastography (SWE). Method: We conducted a prospective study of 13 children with CP (six females and seven males, median age 5y 1mo [interquartile range 4y 4mo–7y 8mo]) and 13 children with typical development (six females and seven males, median age 5y 3mo [interquartile range 4y 4mo–9y 4mo]). Demographic information and physical exam measurements were obtained in addition to shear modulus measurements (passive muscle stiffness) of the lateral gastrocnemius muscle at 20° plantar flexion, 10° plantar flexion, and 0° plantar flexion using SWE. Results: Children with CP had significantly greater shear modulus measurements at all three foot positions (p<0.050). When the shear modulus values were normalized to the baseline value for each child, there was no significant difference between the two groups. Interpretation: Passive muscle stiffness, measured without the influence of spasticity, is greater in children with CP than in children with typical development when a muscle is at slack and at stretch. When shear modulus was normalized, the results indicate that muscle in children in both groups responds similarly to passive stretch. Further work includes evaluating effect of botulinum toxin on passive muscle properties.
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U2 - 10.1111/dmcn.13179
DO - 10.1111/dmcn.13179
M3 - Article
C2 - 27374483
AN - SCOPUS:84978145277
VL - 58
SP - 1288
EP - 1294
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
SN - 0012-1622
IS - 12
ER -