Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography

Yu Hua Fang, Tsair Kao, Liang Chih Wu, Ren Shyan Liu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of Medical and Biological Engineering
Volume23
Issue number3
Publication statusPublished - 2003 Sep 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Quantitative Analysis of <sup>11</sup>C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography'. Together they form a unique fingerprint.

Cite this