Abstract
Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 97-102 |
| Number of pages | 6 |
| Journal | Journal of Medical and Biological Engineering |
| Volume | 23 |
| Issue number | 3 |
| Publication status | Published - 2003 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Biomedical Engineering
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Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography. / Fang, Yu Hua; Kao, Tsair; Wu, Liang Chih; Liu, Ren Shyan.
In: Journal of Medical and Biological Engineering, Vol. 23, No. 3, 01.09.2003, p. 97-102.Research output: Contribution to journal › Article
TY - JOUR
T1 - Quantitative Analysis of 11C-acetate in Nasopharyngeal Carcinoma with Positron Emission Tomography
AU - Fang, Yu Hua
AU - Kao, Tsair
AU - Wu, Liang Chih
AU - Liu, Ren Shyan
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.
AB - Although several kinetic models have been proposed for myocardium 11C-acetate PET quantitative studies, currently there are no reports applying them to tumor diagnosis. In this study, we adopted one of the existing models for performing quantitative analysis on nasopharynx carcinoma (NPC) patients. Ten patients were included, with five NPC and five control subjects. For each subject, one ROI of nasopharynx area and one ROI of muscle area were drawn on PET images. Four rate constants were then estimated using the non-linear least squares method. The extraction fraction K was calculated from these estimated parameters. We found K showed significant difference in the two groups, while the average K of nasopharynx areas was 0.2675 ± 0.1562 in NPC and 0.0763 ± 0.0425 in control patients. In addition, a higher 11C-acetate inflow rate constant from plasma was observed in the NPC nasopharynx area, while the clearance rate was lower. Meanwhile, the rate constants of muscle area in the two groups showed no significant difference. These results indicate that, for tumors, those estimated parameters will be significantly different due to the characteristics of 11C-acetate uptake. In conclusion, our results proved the portability of applying kinetic model analysis in 11C-acetate tumor studies. Such an analysis can provide physicians with objective reference for clinical diagnosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0347994008&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0347994008
VL - 23
SP - 97
EP - 102
JO - Journal of Medical and Biological Engineering
JF - Journal of Medical and Biological Engineering
SN - 1609-0985
IS - 3
ER -