Quantitative profile of estrogen receptor variants/isoforms in Taiwanese women with breast cancer

W. C. Hsiao, W. C. Cho, P. W. Lin, S. L. Lin, W. Y. Lee, K. C. Young

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: To quantify ER variants/isoforms for women with breast cancer in Taiwan, an area with remarkably low breast cancer rates, but with an early onset and poor prognosis. Methods: Real-time PCR technology was exploited to quantify mRNAs of ERα, ERαE3Δ, ERαE5Δ, ERαE7Δ and ERβ, in 49 breast cancer and paired adjacent normal tissues. Clinical parameters were assembled and tested for assocation with the ER expression. Results: Comparison of cancer and matched normal samples showed significantly decreased ERβ (p<0.001) in cancer tissues, and constant amounts of ERα and their variants. The results revealed significantly lower ERαE7Δ/ERα (p=0.030) and ERβ/ERα (p=0.035) ratios in patients with lymph node (LN) metastasis than in those without LN metastasis. Conclusion: Our data suggests that ERαE7Δ and ERβ may regulate ERα in normal human breast tissue.

Original languageEnglish
Pages (from-to)492-497
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume32
Issue number5
DOIs
Publication statusPublished - 2006 Jun 1

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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