Quantitative Targeted Screening of Proteins Associated with Lung Adenocarcinoma by the Method of Selected Reaction Monitoring

A. T. Kopylov, O. V. Tikhonova, T. E. Farafonova, S. E. Novikova, N. A. Shushkova, V. E. Shevchenko, Pao Chi Liao, A. I. Archakov, V. G. Zgoda

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract—Using selected reaction monitoring (SRM) a targeted analysis of proteins that were previously reported to be associated with lung cancer (Novikova, S.E. et al., Biomeditsinskaya khimiya, 2017, vol. 63, pp. 181−210 [1]) was carried out. Measurements were performed using: 23 samples of plasma of patients with lung adenocarcinoma (LAC), 11 samples of plasma of patients with squamous cell lung carcinoma (SqCC), 25 samples of healthy donors. Analysis of plasma protein concentrations has shown that among 52 proteins registered by SRM statistically significant changes were found only for 8 proteins; five of them increased in the group of lung cancer patients (P00738, P26639, P21926, P08603, P51149), while plasma concentrations of three proteins (P51884, O15162, Q8N2K0) were lower than in control. Comparison of plasma protein concentrations in lung cancer patients did not reveal statistically significant changes between LAC and SqCC. These potential biomarkers can be used for \development of methods for early diagnostics of lung cancer.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalBiochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume13
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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