Abstract
| Original language | English |
|---|---|
| Patent number | 9351941 |
| Publication status | Published - 2013 Dec 19 |
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RADIOFREQUENCY-INDUCED SYNCHRONIZATION OF IN SITU HYPERTHERMIA AND CHEMOTHERAPY VIA MAGNETIC-NANOCONJUGATES. / Shieh, Dar-Bin (Inventor).
Patent No.: 9351941.Research output: Patent
TY - PAT
T1 - RADIOFREQUENCY-INDUCED SYNCHRONIZATION OF IN SITU HYPERTHERMIA AND CHEMOTHERAPY VIA MAGNETIC-NANOCONJUGATES
AU - Shieh, Dar-Bin
PY - 2013/12/19
Y1 - 2013/12/19
N2 - The present invention relates to a magnetic nanoparticle for tumor therapy, comprising: a magnetic core; a shell encapsulating a surface of the magnetic core, wherein the shell is made of a polymer with carboxylic groups; a poly-nucleotide chain connected to a surface of the shell; an anti-tumor drug connected to the poly-nucleotide chain, wherein the anti-tumor drug comprises at least one functional group, and each of the functional group is independently a pyrimidine group or a purine group; and an antibody connected to the shell, wherein the antibody identifies a target tumor. In addition, the present invention further provides a method for manufacturing the magnetic nanoparticles for tumor therapy and a pharmaceutical composition containing the magnetic nanoparticles. Accordingly, the magnetic nanoparticle for tumor therapy of the present invention can achieve effective treatment of tumor by synergistic effects between hyperthermia and targeted chemotherapy.
AB - The present invention relates to a magnetic nanoparticle for tumor therapy, comprising: a magnetic core; a shell encapsulating a surface of the magnetic core, wherein the shell is made of a polymer with carboxylic groups; a poly-nucleotide chain connected to a surface of the shell; an anti-tumor drug connected to the poly-nucleotide chain, wherein the anti-tumor drug comprises at least one functional group, and each of the functional group is independently a pyrimidine group or a purine group; and an antibody connected to the shell, wherein the antibody identifies a target tumor. In addition, the present invention further provides a method for manufacturing the magnetic nanoparticles for tumor therapy and a pharmaceutical composition containing the magnetic nanoparticles. Accordingly, the magnetic nanoparticle for tumor therapy of the present invention can achieve effective treatment of tumor by synergistic effects between hyperthermia and targeted chemotherapy.
M3 - Patent
M1 - 9351941
ER -