RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese

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Abstract

Objectives: There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients. Methods: We examined the polymorphisms at the promoter positions -28 and -403 of this gene in 151 Chinese RA patients and 149 ethnically matched healthy controls. Results: The genotypic frequencies in this study were in Hardy-Weinberg equilibrium. RA patients had significantly higher frequencies of the A allele (36.1 % vs. 27.5%, p = 0.024) and A/A genotype (odds ratio [OR] = 3.3, 95% confidence interval [CI] = 1.4-7.9, p = 0.005) at the promoter -403 position. Differences in allele and genotype frequencies at the promoter -28 position between patients and controls were not statistically significant (for G allele, p = 0.103 and for genotype, p = 0.106). RA patients also had a significantly higher frequency of the -28 C/G with -403 A/A compound genotype (OR = 4.6, 95% CI = 1.5-14.5, p = 0.005), and a higher frequency of the -28 G/-403 A haplotype with marginal statistical significance (OR = 1.7, 95% CI = 1.0-3.1, p = 0. 059). Conclusion: Our results indicate that polymorphism in the promoter region of RANTES gene is associated with the susceptibility to RA in the Chinese population.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalClinical and Experimental Rheumatology
Volume23
Issue number3
Publication statusPublished - 2005 May 1

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Chemokine CCL5
Rheumatoid Arthritis
Genotype
Odds Ratio
Confidence Intervals
Gene Frequency
Genes
Genetic Promoter Regions
Haplotypes
Alleles
Population

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology

Cite this

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title = "RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese",
abstract = "Objectives: There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients. Methods: We examined the polymorphisms at the promoter positions -28 and -403 of this gene in 151 Chinese RA patients and 149 ethnically matched healthy controls. Results: The genotypic frequencies in this study were in Hardy-Weinberg equilibrium. RA patients had significantly higher frequencies of the A allele (36.1 {\%} vs. 27.5{\%}, p = 0.024) and A/A genotype (odds ratio [OR] = 3.3, 95{\%} confidence interval [CI] = 1.4-7.9, p = 0.005) at the promoter -403 position. Differences in allele and genotype frequencies at the promoter -28 position between patients and controls were not statistically significant (for G allele, p = 0.103 and for genotype, p = 0.106). RA patients also had a significantly higher frequency of the -28 C/G with -403 A/A compound genotype (OR = 4.6, 95{\%} CI = 1.5-14.5, p = 0.005), and a higher frequency of the -28 G/-403 A haplotype with marginal statistical significance (OR = 1.7, 95{\%} CI = 1.0-3.1, p = 0. 059). Conclusion: Our results indicate that polymorphism in the promoter region of RANTES gene is associated with the susceptibility to RA in the Chinese population.",
author = "Chrong-Reen Wang and How-Ran Guo and Ming-Fei Liu",
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RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese. / Wang, Chrong-Reen; Guo, How-Ran; Liu, Ming-Fei.

In: Clinical and Experimental Rheumatology, Vol. 23, No. 3, 01.05.2005, p. 379-384.

Research output: Contribution to journalArticle

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N2 - Objectives: There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients. Methods: We examined the polymorphisms at the promoter positions -28 and -403 of this gene in 151 Chinese RA patients and 149 ethnically matched healthy controls. Results: The genotypic frequencies in this study were in Hardy-Weinberg equilibrium. RA patients had significantly higher frequencies of the A allele (36.1 % vs. 27.5%, p = 0.024) and A/A genotype (odds ratio [OR] = 3.3, 95% confidence interval [CI] = 1.4-7.9, p = 0.005) at the promoter -403 position. Differences in allele and genotype frequencies at the promoter -28 position between patients and controls were not statistically significant (for G allele, p = 0.103 and for genotype, p = 0.106). RA patients also had a significantly higher frequency of the -28 C/G with -403 A/A compound genotype (OR = 4.6, 95% CI = 1.5-14.5, p = 0.005), and a higher frequency of the -28 G/-403 A haplotype with marginal statistical significance (OR = 1.7, 95% CI = 1.0-3.1, p = 0. 059). Conclusion: Our results indicate that polymorphism in the promoter region of RANTES gene is associated with the susceptibility to RA in the Chinese population.

AB - Objectives: There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients. Methods: We examined the polymorphisms at the promoter positions -28 and -403 of this gene in 151 Chinese RA patients and 149 ethnically matched healthy controls. Results: The genotypic frequencies in this study were in Hardy-Weinberg equilibrium. RA patients had significantly higher frequencies of the A allele (36.1 % vs. 27.5%, p = 0.024) and A/A genotype (odds ratio [OR] = 3.3, 95% confidence interval [CI] = 1.4-7.9, p = 0.005) at the promoter -403 position. Differences in allele and genotype frequencies at the promoter -28 position between patients and controls were not statistically significant (for G allele, p = 0.103 and for genotype, p = 0.106). RA patients also had a significantly higher frequency of the -28 C/G with -403 A/A compound genotype (OR = 4.6, 95% CI = 1.5-14.5, p = 0.005), and a higher frequency of the -28 G/-403 A haplotype with marginal statistical significance (OR = 1.7, 95% CI = 1.0-3.1, p = 0. 059). Conclusion: Our results indicate that polymorphism in the promoter region of RANTES gene is associated with the susceptibility to RA in the Chinese population.

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