Rapid analysis of formaldehyde in food utilizing microfluidic mixer chip

Chien Hsiung Tsai, Che Hsin Lin, Wen Bo Luo, Jik Chang Leong, Zhan Jiong Liu, Lung Ming Fu

Research output: Contribution to journalArticlepeer-review


This work uses microfluidic chip with laser-induced fluorescence detection technique to detect inappropriate additives to food. In the experimental study, 4-amino-3-penten-2-one (Fluoral-P) and formaldehyde chemically interacted in a 3D circular microfluidic mixer while the absorption and fluorescence intensity (of formaldehyde) were confirmed via rapid detection of fluorescence derivatization. If the concentration of the formaldehyde derivatization in the microfluidic chip is too high, the full wavelength of detection can be interfered causing the detection performance to deteriorate. Therefore, the concentration of the formaldehyde for detection in the microfluidic chip must be less than 100 ppm. This study uses a microfluidic mixer having a 1:7 type unbalanced micro-channel. When performing fluorescence intensity detection of formaldehyde derivatization, the fluorescence signal became flatter and the presence of noise was more likely as the concentration of formaldehyde was decreased. The limitation on this concentration was about 0.4 ppm (R 2=0.9954); if less than 1 ppm, the S/N ratio reduced accordingly. In this study, microfluidic mixer chip for rapid analysis of formaldehyde has been proven feasible, with shorter time, less reagent, and lower cost.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalGongneng Cailiao yu Qijian Xuebao/Journal of Functional Materials and Devices
Issue number2
Publication statusPublished - 2008 Apr

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Materials Chemistry


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