Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

Jinglun Li, Ko Wei Chang, Ching Hsuan Yang, Shu-Chu Shiesh, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1951-1953
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14-10-2614-10-30

Fingerprint

Hemoglobin
Medical problems
Microfluidics
Assays
Monitoring
Nucleic acids
Processing

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Li, J., Chang, K. W., Yang, C. H., Shiesh, S-C., & Lee, G. B. (2014). Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 1951-1953). Chemical and Biological Microsystems Society.
Li, Jinglun ; Chang, Ko Wei ; Yang, Ching Hsuan ; Shiesh, Shu-Chu ; Lee, Gwo Bin. / Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 1951-1953
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abstract = "Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.",
author = "Jinglun Li and Chang, {Ko Wei} and Yang, {Ching Hsuan} and Shu-Chu Shiesh and Lee, {Gwo Bin}",
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Li, J, Chang, KW, Yang, CH, Shiesh, S-C & Lee, GB 2014, Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 1951-1953, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 14-10-26.

Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. / Li, Jinglun; Chang, Ko Wei; Yang, Ching Hsuan; Shiesh, Shu-Chu; Lee, Gwo Bin.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1951-1953.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Lee, Gwo Bin

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N2 - Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

AB - Diabetes requires an on-site routine monitoring on a daily basis. In this study, a compact, integrated microfluidic system capable of rapidly measuring the value of glycated hemoglobin (HbA1c) was reported. Since nucleic-acid aptamers with high sensitivity and specificity to hemoglobin and HbA1c were used, the two-aptamer assay can perform the detection of HbA1c within a short period of time. Furthermore, the microfluidic system is extended to parallel processing such that multiple assays can be realized on a single chip. Therefore, it may be promising for providing a diagnostic device for diabetes patients in the near future.

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Li J, Chang KW, Yang CH, Shiesh S-C, Lee GB. Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 1951-1953