Rapid diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective α-fucosidase inhibitors

Chung Yi Wu, Chuan Fa Chang, Jenny Szu Yu Chen, Chi Huey Wong, Chun Hung Lin

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

An efficient and simple method has been developed to identify potent and selective inhibitors against α-fucosidases based on the amide-forming reaction in a microtiter plate of a fuconojirimycin core with various carboxylic acids, followed by a direct inhibition assay without product isolation. The structures of the two most potent inhibitors are shown.

Original languageEnglish
Pages (from-to)4661-4664
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number38
DOIs
Publication statusPublished - 2003 Oct 6

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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