TY - JOUR
T1 - Rapid fabrication of microfluidic paper-based analytical devices by microembossing
AU - Juang, Yi Je
AU - Chen, Po Sheng
AU - Wang, Yu
N1 - Funding Information:
The authors are grateful for the financial support from Ministry of Science and Technology (MOST) in Taiwan (MOST 106-2221-E-006-187 , 107-2221-E-006-103-MY3 ).
Funding Information:
The authors are grateful for the financial support from Ministry of Science and Technology (MOST) in Taiwan (MOST 106-2221-E-006-187, 107-2221-E-006-103-MY3).
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.
AB - In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.
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U2 - 10.1016/j.snb.2018.12.004
DO - 10.1016/j.snb.2018.12.004
M3 - Article
AN - SCOPUS:85057579413
VL - 283
SP - 87
EP - 92
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
SN - 0925-4005
ER -