Rapid fabrication of microfluidic paper-based analytical devices by microembossing

Yi-Je Juang, Po Sheng Chen, Yu Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume283
DOIs
Publication statusPublished - 2019 Mar 15

Fingerprint

Waxes
Microfluidics
Glucose
Heating
Fabrication
embossing
fabrication
waxes
filters
glucose
heating
Processing

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

@article{ecfb6caa56214e618ab331081cf00814,
title = "Rapid fabrication of microfluidic paper-based analytical devices by microembossing",
abstract = "In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.",
author = "Yi-Je Juang and Chen, {Po Sheng} and Yu Wang",
year = "2019",
month = "3",
day = "15",
doi = "10.1016/j.snb.2018.12.004",
language = "English",
volume = "283",
pages = "87--92",
journal = "Sensors and Actuators, B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

Rapid fabrication of microfluidic paper-based analytical devices by microembossing. / Juang, Yi-Je; Chen, Po Sheng; Wang, Yu.

In: Sensors and Actuators, B: Chemical, Vol. 283, 15.03.2019, p. 87-92.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rapid fabrication of microfluidic paper-based analytical devices by microembossing

AU - Juang, Yi-Je

AU - Chen, Po Sheng

AU - Wang, Yu

PY - 2019/3/15

Y1 - 2019/3/15

N2 - In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.

AB - In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.

UR - http://www.scopus.com/inward/record.url?scp=85057579413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057579413&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2018.12.004

DO - 10.1016/j.snb.2018.12.004

M3 - Article

AN - SCOPUS:85057579413

VL - 283

SP - 87

EP - 92

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

SN - 0925-4005

ER -