Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Feng Wei Lin; Pin Yuan Chen; Kuo Chen Wei; Chiung Yin Huang; Chih Kuang Wang; Hung Wei Yang

doi:10.7150/thno.19856

Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Feng Wei Lin, Pin Yuan Chen, Kuo Chen Wei, Chiung Yin Huang, Chih Kuang Wang, Hung Wei Yang

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

Original language	English
Pages (from-to)	2524-2536
Number of pages	13
Journal	Theranostics
Volume	7
Issue number	9
DOIs	https://doi.org/10.7150/thno.19856
Publication status	Published - 2017

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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title = "Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor",

abstract = "Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.",

author = "Lin, {Feng Wei} and Chen, {Pin Yuan} and Wei, {Kuo Chen} and Huang, {Chiung Yin} and Wang, {Chih Kuang} and Yang, {Hung Wei}",

note = "Funding Information: We thank the Ministry of Science and Technology, Chang Gung Memorial Hospital, and National Health Research Institutes, Taiwan (R.O.C.), for the financial assistance provided (MOST103-2320-B-110-004-MY2, MOST105-2314-B-110-001, CMRPG3F1731, CIRPG3E2041, and NHRI-EX106-10502NI). We would also like to thank Ms. Li-Ying Feng, Chang Gung Memorial Hospital Microscopy Core Laboratory, and Center for Advanced Molecular Imaging and Translation for assistance with Immunohistochemistry, TEM, and MRI. Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

doi = "10.7150/thno.19856",

language = "English",

volume = "7",

pages = "2524--2536",

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TY - JOUR

T1 - Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

AU - Lin, Feng Wei

AU - Chen, Pin Yuan

AU - Wei, Kuo Chen

AU - Huang, Chiung Yin

AU - Wang, Chih Kuang

AU - Yang, Hung Wei

N1 - Funding Information: We thank the Ministry of Science and Technology, Chang Gung Memorial Hospital, and National Health Research Institutes, Taiwan (R.O.C.), for the financial assistance provided (MOST103-2320-B-110-004-MY2, MOST105-2314-B-110-001, CMRPG3F1731, CIRPG3E2041, and NHRI-EX106-10502NI). We would also like to thank Ms. Li-Ying Feng, Chang Gung Memorial Hospital Microscopy Core Laboratory, and Center for Advanced Molecular Imaging and Translation for assistance with Immunohistochemistry, TEM, and MRI. Publisher Copyright: © Ivyspring International Publisher.

PY - 2017

Y1 - 2017

N2 - Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

AB - Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogelGd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

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Rapid in situ MRI traceable gel-forming dual-drug delivery for synergistic therapy of brain tumor

Abstract

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