Rapidly self-expandable polymeric stents with a shape-memory property

Mei Chin Chen, Hung Wen Tsai, Yen Chang, Wei Yun Lai, Fwu Long Mi, Chin Tang Liu, Hen Sheng Wong, Hsing Wen Sung

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

A novel biodegradable stent, made of chitosan films cross-linked with an epoxy compound, with a shape-memory property was developed. To reduce their crystallinity, glycerol and poly(ethylene oxide) were blended in the chitosan films. The mechanical properties of the prepared stent were studied using a commercially available metallic stent as a control. After blending, the ductility of the chitosan films was improved, and the compressive strength of the stent was significantly enhanced. The metallic stent could tolerate elastic deformations of 10% before becoming irreversibly deformed, while the polymeric stent was able to withstand deformations up to 30% and still regain its original configuration. The developed stent could rapidly expand (∼150 s) from its crimped (temporary) to fully expanded (permanent) states stimulated by hydration, which is advantageous considering avoiding its migration during in vivo deployment. In the preliminary animal study, the implanted stent was found to be intact, and no thrombus formation was seen in the stent-implanted vessel. This degradable stent can be an attractive alternative to metallic stents and may serve as a useful vehicle for local drug delivery.

Original languageEnglish
Pages (from-to)2774-2780
Number of pages7
JournalBiomacromolecules
Volume8
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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    Chen, M. C., Tsai, H. W., Chang, Y., Lai, W. Y., Mi, F. L., Liu, C. T., Wong, H. S., & Sung, H. W. (2007). Rapidly self-expandable polymeric stents with a shape-memory property. Biomacromolecules, 8(9), 2774-2780. https://doi.org/10.1021/bm7004615