TY - JOUR
T1 - Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation
AU - Shibata, Youichi
AU - Kamata, Tohru
AU - Kimura, Motoko
AU - Yamashita, Masakatsu
AU - Wang, Chrong Reen
AU - Murata, Kaoru
AU - Miyazaki, Masaru
AU - Taniguchi, Masaru
AU - Watanabe, Naohiro
AU - Nakayama, Toshinori
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/8/15
Y1 - 2002/8/15
N2 - The central role for Th2 cells in the development of Ag-induced airway hyperresponsiveness and eosinophilic inflammation is well documented. We have reported a crucial role for TCR-induced activation of the Ras/extracellular signal-regulated kinase mitogenactivated protein kinase cascade in Th2 cell differentiation. Here, we show that the development of both OVA-induced airway hyperresponsiveness and eosinophilic airway inflammation in a mouse asthma model are attenuated in transgenic mice by the overexpression of enzymatically inactive Ras molecules in T cells. In addition, reduced levels of IL-5 production and eosinophilic inflammation induced by nematode infection (Nippostrongylus brasiliensis or Heligmosomoides polygyrus) were detected. Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness.
AB - The central role for Th2 cells in the development of Ag-induced airway hyperresponsiveness and eosinophilic inflammation is well documented. We have reported a crucial role for TCR-induced activation of the Ras/extracellular signal-regulated kinase mitogenactivated protein kinase cascade in Th2 cell differentiation. Here, we show that the development of both OVA-induced airway hyperresponsiveness and eosinophilic airway inflammation in a mouse asthma model are attenuated in transgenic mice by the overexpression of enzymatically inactive Ras molecules in T cells. In addition, reduced levels of IL-5 production and eosinophilic inflammation induced by nematode infection (Nippostrongylus brasiliensis or Heligmosomoides polygyrus) were detected. Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness.
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U2 - 10.4049/jimmunol.169.4.2134
DO - 10.4049/jimmunol.169.4.2134
M3 - Article
C2 - 12165542
AN - SCOPUS:0037103264
VL - 169
SP - 2134
EP - 2140
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -