Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation

Youichi Shibata, Tohru Kamata, Motoko Kimura, Masakatsu Yamashita, Chrong Reen Wang, Kaoru Murata, Masaru Miyazaki, Masaru Taniguchi, Naohiro Watanabe, Toshinori Nakayama

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The central role for Th2 cells in the development of Ag-induced airway hyperresponsiveness and eosinophilic inflammation is well documented. We have reported a crucial role for TCR-induced activation of the Ras/extracellular signal-regulated kinase mitogenactivated protein kinase cascade in Th2 cell differentiation. Here, we show that the development of both OVA-induced airway hyperresponsiveness and eosinophilic airway inflammation in a mouse asthma model are attenuated in transgenic mice by the overexpression of enzymatically inactive Ras molecules in T cells. In addition, reduced levels of IL-5 production and eosinophilic inflammation induced by nematode infection (Nippostrongylus brasiliensis or Heligmosomoides polygyrus) were detected. Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness.

Original languageEnglish
Pages (from-to)2134-2140
Number of pages7
JournalJournal of Immunology
Volume169
Issue number4
DOIs
Publication statusPublished - 2002 Aug 15

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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