Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation

Youichi Shibata, Tohru Kamata, Motoko Kimura, Masakatsu Yamashita, Chrong Reen Wang, Kaoru Murata, Masaru Miyazaki, Masaru Taniguchi, Naohiro Watanabe, Toshinori Nakayama

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27 Citations (Scopus)

Abstract

The central role for Th2 cells in the development of Ag-induced airway hyperresponsiveness and eosinophilic inflammation is well documented. We have reported a crucial role for TCR-induced activation of the Ras/extracellular signal-regulated kinase mitogenactivated protein kinase cascade in Th2 cell differentiation. Here, we show that the development of both OVA-induced airway hyperresponsiveness and eosinophilic airway inflammation in a mouse asthma model are attenuated in transgenic mice by the overexpression of enzymatically inactive Ras molecules in T cells. In addition, reduced levels of IL-5 production and eosinophilic inflammation induced by nematode infection (Nippostrongylus brasiliensis or Heligmosomoides polygyrus) were detected. Thus, the level of Ras activation in T cells appears to determine Th2-dependent eosinophilic inflammation and Ag-induced airway hyperresponsiveness.

Original languageEnglish
Pages (from-to)2134-2140
Number of pages7
JournalJournal of Immunology
Volume169
Issue number4
DOIs
Publication statusPublished - 2002 Aug 15

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C. R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N., & Nakayama, T. (2002). Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. Journal of Immunology, 169(4), 2134-2140. https://doi.org/10.4049/jimmunol.169.4.2134