Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection

Yung Chun Chuang, Shu-Ying Wang, Yee-Shin Lin, Hong Ru Chen, Trai-Ming Yeh

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in these patients. From previous studies, it is known that both antibodies and cytokines induced in response to DENV infection are involved in the immunopathogenesis of DHF/DSS. However, the role of viral factors during DENV infection remains unclear. Nonstructural protein 1 (NS1), which is secreted in the sera of patients, is a useful diagnostic marker for acute DENV infection. Nevertheless, the roles of NS1 and its antibodies in the pathogenesis of DHF/DSS are unclear. The focus of this review is to evaluate the possible contributions of NS1 and the antibodies it induces to vascular leakage and abnormal hemorrhage during DENV infection, which may provide clues to better understanding the pathogenesis of DHF/DSS.

Original languageEnglish
Article number42
JournalJournal of biomedical science
Volume20
Issue number1
DOIs
Publication statusPublished - 2013 Jul 2

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Severe Dengue
Dengue Virus
Virus Diseases
Viruses
Antibodies
Proteins
Blood Vessels
Cytokines
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

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abstract = "Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in these patients. From previous studies, it is known that both antibodies and cytokines induced in response to DENV infection are involved in the immunopathogenesis of DHF/DSS. However, the role of viral factors during DENV infection remains unclear. Nonstructural protein 1 (NS1), which is secreted in the sera of patients, is a useful diagnostic marker for acute DENV infection. Nevertheless, the roles of NS1 and its antibodies in the pathogenesis of DHF/DSS are unclear. The focus of this review is to evaluate the possible contributions of NS1 and the antibodies it induces to vascular leakage and abnormal hemorrhage during DENV infection, which may provide clues to better understanding the pathogenesis of DHF/DSS.",
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Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection. / Chuang, Yung Chun; Wang, Shu-Ying; Lin, Yee-Shin; Chen, Hong Ru; Yeh, Trai-Ming.

In: Journal of biomedical science, Vol. 20, No. 1, 42, 02.07.2013.

Research output: Contribution to journalReview article

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