TY - JOUR
T1 - Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection
AU - Chuang, Yung Chun
AU - Wang, Shu Ying
AU - Lin, Yee Shin
AU - Chen, Hong Ru
AU - Yeh, Trai Ming
N1 - Funding Information:
This work was supported by a grant from the National Science Council of Taiwan [NSC-101-2321-B-039-009-MY3]. We thank Michael M. C. Lai for help in the revision of this manuscript.
PY - 2013
Y1 - 2013
N2 - Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in these patients. From previous studies, it is known that both antibodies and cytokines induced in response to DENV infection are involved in the immunopathogenesis of DHF/DSS. However, the role of viral factors during DENV infection remains unclear. Nonstructural protein 1 (NS1), which is secreted in the sera of patients, is a useful diagnostic marker for acute DENV infection. Nevertheless, the roles of NS1 and its antibodies in the pathogenesis of DHF/DSS are unclear. The focus of this review is to evaluate the possible contributions of NS1 and the antibodies it induces to vascular leakage and abnormal hemorrhage during DENV infection, which may provide clues to better understanding the pathogenesis of DHF/DSS.
AB - Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in these patients. From previous studies, it is known that both antibodies and cytokines induced in response to DENV infection are involved in the immunopathogenesis of DHF/DSS. However, the role of viral factors during DENV infection remains unclear. Nonstructural protein 1 (NS1), which is secreted in the sera of patients, is a useful diagnostic marker for acute DENV infection. Nevertheless, the roles of NS1 and its antibodies in the pathogenesis of DHF/DSS are unclear. The focus of this review is to evaluate the possible contributions of NS1 and the antibodies it induces to vascular leakage and abnormal hemorrhage during DENV infection, which may provide clues to better understanding the pathogenesis of DHF/DSS.
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U2 - 10.1186/1423-0127-20-42
DO - 10.1186/1423-0127-20-42
M3 - Review article
C2 - 23806052
AN - SCOPUS:84879445032
SN - 1021-7770
VL - 20
JO - Journal of biomedical science
JF - Journal of biomedical science
IS - 1
M1 - 42
ER -