Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment

Cheng Kang Tang, Yu Hsien Lin, Joe Air Jiang, Yun Heng Lu, Chih Hsuan Tsai, Yu Chun Lin, Yun Ru Chen, Carol P. Wu, Yueh Lung Wu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Impairment in the learning/memory behavior of bees is responsible for the massive disappearance of bee populations and its consequent agricultural economic losses. Such impairment might be because of o both pesticide exposure and pathogen infection, with a key contributor deformed wing virus (DWV). The present study found that sodium butyrate (NaB) significantly increased survival and reversed the learning/memory impairment of DWV-infected bees. A next-generation sequencing analysis showed that NaB affected the expression of genes involved in glycolytic processes and memory formation, which were suppressed by DWV infection. In addition, we performed a large-scale movement tracking experiment by using a wireless sensor network-based automatic real-time monitoring system and confirmed that NaB could improve the homing ability of DWV-infected bees. In short, we demonstrated the mechanism of how epigenetic regulation can resume the memory function of honeybees and suggest strategies for applying NaB to reduce the incidence of colony losses.

Original languageEnglish
Article number103056
JournaliScience
Volume24
Issue number10
DOIs
Publication statusPublished - 2021 Oct 22

All Science Journal Classification (ASJC) codes

  • General

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