TY - JOUR
T1 - Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules
AU - Chen, Mei Chin
AU - Mi, Fwu Long
AU - Liao, Zi Xian
AU - Hsiao, Chun Wen
AU - Sonaje, Kiran
AU - Chung, Min Fan
AU - Hsu, Li Wen
AU - Sung, Hsing Wen
N1 - Funding Information:
The authors would like to thank the National Science Council of the Republic of China, Taiwan , for financially supporting this research under contract no. NSC 100-2120-M-007-003 . We are grateful to our collaborators for their tremendous contributions to this project.
PY - 2013/6/15
Y1 - 2013/6/15
N2 - Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.
AB - Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive feature and ability to modulate the integrity of epithelial tight junctions reversibly. By using CS-based nanoparticles, many studies have attempted to protect the loaded macromolecules against acidic denaturation and enzymatic degradation, prolong their intestinal residence time, and increase their absorption by the intestinal epithelium. Derivatives of CS such as quaternized CS, thiolated CS and carboxylated CS have also been examined to further enhance its effectiveness in oral absorption of macromolecular drugs. This review article describes the synthesis of these CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane. Recent advances in using CS and its derivatives as carriers for oral delivery of hydrophilic macromolecules and their effects on drug transport are also reviewed.
UR - http://www.scopus.com/inward/record.url?scp=84878862620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878862620&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2012.10.010
DO - 10.1016/j.addr.2012.10.010
M3 - Review article
C2 - 23159541
AN - SCOPUS:84878862620
VL - 65
SP - 865
EP - 879
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 6
ER -