Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review

Yi Han Chang, Hsin Yi Hung

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Obesity is not only viewed as a chronic aggressive disorder but is also associated with an increased risk for various diseases. Nonetheless, new anti-obesity drugs are an urgent need since few pharmacological choices are available on the market. Natural compounds have served as templates for drug discovery, whereas modified molecules from the leads identified based on in vitro models often reveal noncorresponding bioactivity between in vitro and in vivo studies. Therefore, to provide inspiration for the exploration of innovative anti-obesity agents, recent discoveries of natural anti-obesity compounds with in vivo evidence have been summarized according to their chemical structures, and the comparable efficacy of these compounds is categorized using animal models. In addition, several synthetic derivatives optimized from the phytochemicals are also provided to discuss medicinal chemistry achievements guided by natural sources.

Original languageEnglish
Article number114405
JournalEuropean Journal of Medicinal Chemistry
Volume237
DOIs
Publication statusPublished - 2022 Jul 5

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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