TY - JOUR
T1 - Recent advances in vascularized tumor-on-a-chip
AU - Huang, Christina Bao Xian
AU - Tu, Ting Yuan
N1 - Funding Information:
The authors are grateful for the support from the Core Research Laboratory, College of Medicine, and the Center for Micro/Nano Science and Technology, NCKU. The authors also thank the service provided by the “Bioimaging Core Facility of the National Core Facility for Biopharmaceuticals, Ministry of Science and Technology, Taiwan”.
Funding Information:
This work was funded by the National Science and Technology Council (NSTC), Taiwan, and the Young Scholar Program (MOST 111- 2740-B-006-002-, MOST 111-2636-B-006-010-, and NSTC 112-2636-B-006-001- to T-YT). This work was also supported in part by the Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. Acknowledgments
Publisher Copyright:
Copyright © 2023 Huang and Tu.
PY - 2023
Y1 - 2023
N2 - The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of replicating in vivo conditions with exceptional spatiotemporal resolution, making it a significant asset in cancer research. This review delves into the latest developments in 3D microfluidic vascularized tumor models and their applications in vitro, focusing on heterotypic cellular interactions, the mechanisms of metastasis, and therapeutic screening. Additionally, the review examines the benefits and drawbacks of these models, as well as the future prospects for their advancement.
AB - The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of replicating in vivo conditions with exceptional spatiotemporal resolution, making it a significant asset in cancer research. This review delves into the latest developments in 3D microfluidic vascularized tumor models and their applications in vitro, focusing on heterotypic cellular interactions, the mechanisms of metastasis, and therapeutic screening. Additionally, the review examines the benefits and drawbacks of these models, as well as the future prospects for their advancement.
UR - http://www.scopus.com/inward/record.url?scp=85153394677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153394677&partnerID=8YFLogxK
U2 - 10.3389/fonc.2023.1150332
DO - 10.3389/fonc.2023.1150332
M3 - Review article
AN - SCOPUS:85153394677
SN - 2234-943X
VL - 13
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1150332
ER -
