Recent advances in yeast cell-surface display technologies for waste biorefineries

Zhuo Liu, Shih Hsin Ho, Tomohisa Hasunuma, Jo Shu Chang, Nan Qi Ren, Akihiko Kondo

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)


Waste biorefinery aims to maximize the output of value-added products from various artificial/agricultural wastes by using integrated bioprocesses. To make waste biorefinery economically feasible, it is thus necessary to develop a low-cost, environment-friendly technique to perform simultaneous biodegradation and bioconversion of waste materials. Cell-surface display engineering is a novel, cost-effective technique that can auto-immobilize proteins on the cell exterior of microorganisms, and has been applied for use with waste biofinery. Through tethering different enzymes (e.g., cellulase, lipase, and protease) or metal-binding peptides on cell surfaces, various yeast strains can effectively produce biofuels and biochemicals from sugar/protein-rich waste materials, catalyze waste oils into biodiesels, or retrieve heavy metals from wastewater. This review critically summarizes recent applications of yeast cell-surface display on various types of waste biorefineries, highlighting its potential and future challenges with regard to commercializing this technology.

Original languageEnglish
Pages (from-to)324-333
Number of pages10
JournalBioresource technology
Publication statusPublished - 2016 Sep 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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