Recent discovery of plant-derived anti-diabetic natural products

Hsin Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau Shin Hsu, Kuo Hsiung Lee

Research output: Contribution to journalReview articlepeer-review

215 Citations (Scopus)


This review covers recent discoveries of anti-diabetic compounds. Diabetes mellitus (DM) is a complex disease affecting patients' daily life and elevating patients' risk of developing other diseases. There are several forms of diabetes, including type-1 diabetes (insulin-dependent), type-2 diabetes (noninsulin-dependent), and gestational diabetes. Type-2 diabetes is the most common form and the patient population with type-2 DM rises every year. Current treatments meet some but not all patients' needs. Therefore, new anti-diabetic drugs are in great demand. Traditional herbal medicine provides a rich source for new drug discovery. In this review, recent discoveries of anti-diabetic compounds have been summarized according to their chemical structures and mechanisms of action. Anti-diabetic plant extracts, many of which have been used and marketed as dietary supplements, were also included and discussed, and are classified according to the positive control used in the anti-diabetic animal studies. New anti-diabetic natural products found in the recent patent literature are also summarized.

Original languageEnglish
Pages (from-to)580-606
Number of pages27
JournalNatural Product Reports
Issue number5
Publication statusPublished - 2012 May

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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