Red Mold Rice against Hepatic Inflammatory Damage in Zn-deficient Rats

Bao Hong Lee, Wei-Hsuan Hsu, Tzu Ming Pan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The protective effect of red mold rice (RMR) against liver injury in rats fed with a Zn-deficient diet for 12 weeks was investigated in this study. Rats were orally administered RMR (151 mg/kg body weight or 755 mg/kg body weight; 1 dose or 5 dose, respectively) with or without Zn once a day for 4 consecutive weeks. The severity of liver damage was evaluated by measuring the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in Zn-deficient rats. RMR significantly inhibited the elevation of serum ALT levels by Zn-deficient induction. Hepatic antioxidase activity was also significantly increased in the RMR + Zn group (RZ), thereby suppressing the productions of reactive oxygen species (ROS) and proinflammatory cytokines in the liver of Zn-deficient rats. These findings suggested that RMR exerted hepatoprotective effects against Zn deficiency-induced liver inflammation.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalJournal of Traditional and Complementary Medicine
Volume2
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Fungi
Liver
Alanine Transaminase
Body Weight
Aspartate Aminotransferases
Serum
Reactive Oxygen Species
Oryza
Cytokines
Diet
Inflammation
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

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abstract = "The protective effect of red mold rice (RMR) against liver injury in rats fed with a Zn-deficient diet for 12 weeks was investigated in this study. Rats were orally administered RMR (151 mg/kg body weight or 755 mg/kg body weight; 1 dose or 5 dose, respectively) with or without Zn once a day for 4 consecutive weeks. The severity of liver damage was evaluated by measuring the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in Zn-deficient rats. RMR significantly inhibited the elevation of serum ALT levels by Zn-deficient induction. Hepatic antioxidase activity was also significantly increased in the RMR + Zn group (RZ), thereby suppressing the productions of reactive oxygen species (ROS) and proinflammatory cytokines in the liver of Zn-deficient rats. These findings suggested that RMR exerted hepatoprotective effects against Zn deficiency-induced liver inflammation.",
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Red Mold Rice against Hepatic Inflammatory Damage in Zn-deficient Rats. / Lee, Bao Hong; Hsu, Wei-Hsuan; Pan, Tzu Ming.

In: Journal of Traditional and Complementary Medicine, Vol. 2, No. 1, 01.01.2012, p. 52-60.

Research output: Contribution to journalArticle

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