Reduced membranous β-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus

Po Kuei Hsu, Anna Fen Yau Li, Yi Ching Wang, Chih Cheng Hsieh, Min Hsiung Huang, Wen Hu Hsu, Han Shui Hsu

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26 Citations (Scopus)

Abstract

Objectives: The aim of this study was to evaluate, by immunohistochemical analysis, the protein expression of β-catenin and p53 in resected esophageal squamous cell carcinoma specimens. The clinical relevance and prognostic significance of the expression of these proteins were also analyzed. Methods: Immunohistochemistry was performed on paraffin-embedded tissue specimens from 68 resected esophageal squamous cell carcinoma tumor specimens to detect the expression of β-catenin and p53. The correlation between the results of immunoexpression and the clinicopathologic parameters and patient survival was processed statistically. Results: Reduced membranous β-catenin expression was noted in 43 (63.2%) of 68 tumor specimens. Increased expression of p53 was observed in 43 (63.2%) of 68 specimens. Reduced membranous β-catenin protein expression was associated with the presence of distant metastasis (P = .006). Patients with reduced membranous β-catenin expression had a worse prognosis than patients with normal membranous β-catenin expression (P = .005). Patients with combined increased p53 and reduced membranous β-catenin protein expression had the worst prognosis (P = .012). In a multivariate survival analysis, reduced membranous β-catenin expression and nodal involvement were independent prognostic factors (P = .004 and .019, respectively). Conclusions: Immunohistochemical analysis revealed that reduced membranous β-catenin protein expression was associated with the presence of distant metastasis and a poor prognosis in patients with esophageal squamous cell carcinoma. Combined increased p53 and reduced membranous β-catenin protein expression indicated a very poor prognosis in patients with esophageal squamous cell carcinoma. Further investigation is needed to understand the roles of β-catenin and p53 in the tumorigenesis and metastasis of esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1029-1035
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume135
Issue number5
DOIs
Publication statusPublished - 2008 May 1

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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