Reference-based model predictive control scheme for fed-batch bioprocess optimization

Wei Wu, Chao Wei Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


In the study, a semianalytie optimization algorithm was used to achieve the suboptimal performance under specific operating constraints of the fed-batch fermentation process. By applying Pontryagin's minimum principle, the substrate feed rate was taken as the manipulated variable and characterized in a piecewise manner. On the basis of the repetitive optimization algorithm, a varied reference was developed by adjusting the switching times and other parameters. The reference-based model prediction strategy was successfully implemented to ensure the satisfactory output regulation, whereas the amount of product obtained was measured separately. The symbolic software Maple™ was used to implement the complete control structure, and the effectiveness of the proposed methodology was verified by performing closed-loop simulation tests.

Original languageEnglish
Pages (from-to)691-699
Number of pages9
Issue number9
Publication statusPublished - 2009 Oct 15

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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