Regulation of nuclear calcium uptake by inositol phosphates and external calcium

Ao Lin Hsu, Pei Jung Lu, Ching Shih Chen

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Factors affecting Ins(1,3,4,5)P4-mediated nuclear Ca2+ uptake are investigated, which include Ins(1,3,4,5)P4 receptor ligand specificity and free external Ca2+ concentrations. Among various inositol phosphates examined, Ins(1,3,4,6)P4, Ins(3,4,5,6)P4, and Ins(1,3,4,5,6)P5 can also stimulate 45Ca2+ influx into isolated rat liver nuclei by activating the Ins(1,3,4,5)P4 receptor-mediated Ca2+ uptake into the nucleus. The EC50 values of these polyphosphates range between 200 and 300 nM, which are 3-4 folds higher than that of Ins(1,3,4,5)P4. It is plausible that these polyphosphates in conjunction with Ins(1,3,4,5)P4 take part in the regulation of nuclear Ca2+ uptake in view of their intracellular levels during cell activation. Moreover, the inositol phosphate-induced Ca2+ uptake is facilitated by increasing Ca2+ levels in the uptake milieu, suggesting a possible link between cytosolic and nuclear Ca2+ signals through the Ins(1,3,4,5)P4 receptor.

Original languageEnglish
Pages (from-to)653-656
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume243
Issue number3
DOIs
Publication statusPublished - 1998 Feb 24

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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