Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly

Chun Hsiang Lin, Yi Ru Shen, Han Yu Wang, Chi-Wu Chiang, Chia-Yih Wang, Pao-Lin Kuo

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The sperm annulus, a septin-based ring structure, is important for reproductive physiology. It is composed of SEPT12-based septin core complex followed by assembling as octameric filament. In clinical examinations, mutations of Septin12 result in male infertility, immotile sperm, as well as sperm with defective annuli. The dynamic assembly of septin filaments is regulated by several post-translational modifications, including sumoylation, acetylation, and phosphorylation. Here, we briefly review the biological significance and the regulation of SEPT12 phosphorylation in the mammalian sperm physiology. During mammalian spermiogenesis, the phosphorylation of SEPT12 on Ser198 residue is important in regulating mammalian annulus architectures. SEPT12 phosphomimetic knock-in mice displayed poor male fertility due to weak sperm motility and loss of the sperm annulus. SEPT12 is phosphorylated via Protein kinase A (PKA), and its phosphorylation interfered with SEPT12 polymerization into complexes and filaments. Taken together, the phosphorylation status of SEPT12 is crucial for its function in regulating the mammalian sperm physiology.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalCytoskeleton
Volume76
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Septins
Spermatozoa
Phosphorylation
Sumoylation
Sperm Motility
Male Infertility
Spermatogenesis
Post Translational Protein Processing
Acetylation
Cyclic AMP-Dependent Protein Kinases
Polymerization
Fertility
Mutation

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Cell Biology

Cite this

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title = "Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly",
abstract = "The sperm annulus, a septin-based ring structure, is important for reproductive physiology. It is composed of SEPT12-based septin core complex followed by assembling as octameric filament. In clinical examinations, mutations of Septin12 result in male infertility, immotile sperm, as well as sperm with defective annuli. The dynamic assembly of septin filaments is regulated by several post-translational modifications, including sumoylation, acetylation, and phosphorylation. Here, we briefly review the biological significance and the regulation of SEPT12 phosphorylation in the mammalian sperm physiology. During mammalian spermiogenesis, the phosphorylation of SEPT12 on Ser198 residue is important in regulating mammalian annulus architectures. SEPT12 phosphomimetic knock-in mice displayed poor male fertility due to weak sperm motility and loss of the sperm annulus. SEPT12 is phosphorylated via Protein kinase A (PKA), and its phosphorylation interfered with SEPT12 polymerization into complexes and filaments. Taken together, the phosphorylation status of SEPT12 is crucial for its function in regulating the mammalian sperm physiology.",
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Regulation of septin phosphorylation : SEPT12 phosphorylation in sperm septin assembly. / Lin, Chun Hsiang; Shen, Yi Ru; Wang, Han Yu; Chiang, Chi-Wu; Wang, Chia-Yih; Kuo, Pao-Lin.

In: Cytoskeleton, Vol. 76, No. 1, 01.01.2019, p. 137-142.

Research output: Contribution to journalReview article

TY - JOUR

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T2 - SEPT12 phosphorylation in sperm septin assembly

AU - Lin, Chun Hsiang

AU - Shen, Yi Ru

AU - Wang, Han Yu

AU - Chiang, Chi-Wu

AU - Wang, Chia-Yih

AU - Kuo, Pao-Lin

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AB - The sperm annulus, a septin-based ring structure, is important for reproductive physiology. It is composed of SEPT12-based septin core complex followed by assembling as octameric filament. In clinical examinations, mutations of Septin12 result in male infertility, immotile sperm, as well as sperm with defective annuli. The dynamic assembly of septin filaments is regulated by several post-translational modifications, including sumoylation, acetylation, and phosphorylation. Here, we briefly review the biological significance and the regulation of SEPT12 phosphorylation in the mammalian sperm physiology. During mammalian spermiogenesis, the phosphorylation of SEPT12 on Ser198 residue is important in regulating mammalian annulus architectures. SEPT12 phosphomimetic knock-in mice displayed poor male fertility due to weak sperm motility and loss of the sperm annulus. SEPT12 is phosphorylated via Protein kinase A (PKA), and its phosphorylation interfered with SEPT12 polymerization into complexes and filaments. Taken together, the phosphorylation status of SEPT12 is crucial for its function in regulating the mammalian sperm physiology.

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