Regulatory effects of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function

Giorgio Senaldi, Marina Stolina, Jane Guo, Raffaella Faggioni, Susan McCabe, Stephen A. Kaufman, Gwyneth Van, Weilong Xu, Frederick A. Fletcher, Thomas Boone, Ming Shi Chang, Ulla Sarmiento, Russell C. Cattley

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33 Citations (Scopus)

Abstract

We describe regulatory effects that a novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3; also reported as cardiotrophin-like cytokine) has on B cell function. NNT-1/BSF-3 stimulates B cell proliferation and Ig production in vitro. NNT-1/BSF-3-transgenic mice, engineered to express NNT-1/BSF-3 in the liver under control of the apolipoprotein E promoter, show B cell hyperplasia with particular expansion of the mature follicular B cell subset in the spleen and the prominent presence of plasma cells. NNT-1/BSF-3-transgenic mice show high serum levels of IgM, IgE, IgG2b, IgG3, anti-dsDNA Abs, and serum amyloid A. NNT-1/BSF-3-transgenic mice also show non-amyloid mesangial deposits that contain IgM, IgG, and C3 and are characterized by a distinctive ultrastructure similar to that of immunotactoid glomerulopathy. NNT-1/BSF-3-transgenic mice produce high amounts of Ag-specific IgM, IgA, and IgE and low amounts of IgG2a and IgG3. Normal mice treated with NNT-1/BSF-3 also produce high amounts of Ag-specific IgE. NNT-1/BSF-3 regulates immunity by stimulating B cell function and Ab production, with preference for Th2 over Thl Ig types.

Original languageEnglish
Pages (from-to)5690-5698
Number of pages9
JournalJournal of Immunology
Volume168
Issue number11
DOIs
Publication statusPublished - 2002 Jun 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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