Rehabilitation for a child with recalcitrant anti-N-methyl-D-aspartate receptor encephalitis: Case report and literature review

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11 Citations (Scopus)

Abstract

Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6–8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs.

Original languageEnglish
Pages (from-to)2263-2267
Number of pages5
JournalNeuropsychiatric Disease and Treatment
Volume10
DOIs
Publication statusPublished - 2014 Nov 24

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Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Encephalitis
Immunotherapy
Rehabilitation
Behavioral Symptoms
Pediatric Intensive Care Units
Motor Skills
Dyskinesias
Activities of Daily Living
Autoimmune Diseases
Intensive Care Units
Neoplasms
Hospitalization
aspartic acid receptor

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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title = "Rehabilitation for a child with recalcitrant anti-N-methyl-D-aspartate receptor encephalitis: Case report and literature review",
abstract = "Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6–8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs.",
author = "Yao-Hong Guo and Da-Shen Kuan and Pei-Chun Hsieh and Wei-Chih Lien and Chun-Kai Chang and Yu-Ching Lin",
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AU - Chang, Chun-Kai

AU - Lin, Yu-Ching

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