Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

Ting Hsing Chao; Yi Heng Li; Jyh Hong Chen; Hua Lin Wu; Guey Yueh Shi; Wei Chuan Tsai; Pin Shern Chen; Ping Yen Liu

doi:10.1016/j.amjcard.2003.09.039

Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

Ting Hsing Chao, Yi Heng Li, Jyh Hong Chen, Hua Lin Wu, Guey Yueh Shi, Wei Chuan Tsai, Pin Shern Chen, Ping Yen Liu

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.

Original language	English
Pages (from-to)	204-207
Number of pages	4
Journal	American Journal of Cardiology
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/j.amjcard.2003.09.039
Publication status	Published - 2004 Jan 15

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2003.09.039

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title = "Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age",

abstract = "Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.",

author = "Chao, {Ting Hsing} and Li, {Yi Heng} and Chen, {Jyh Hong} and Wu, {Hua Lin} and Shi, {Guey Yueh} and Tsai, {Wei Chuan} and Chen, {Pin Shern} and Liu, {Ping Yen}",

note = "Funding Information: This study was supported by the MOE Program, Tainan, Taiwan, for Promoting Academic Excellent of Universities under grant number 91-B-FA09-2-4 and by the National Science Council, Executive Yuan, Taipei, Taiwan, under grant numbers NSC-89-2314-B-006-029 and NSC-89-2314-B-006-172. ",

year = "2004",

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doi = "10.1016/j.amjcard.2003.09.039",

language = "English",

volume = "93",

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journal = "American Journal of Cardiology",

issn = "0002-9149",

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T1 - Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

AU - Chao, Ting Hsing

AU - Li, Yi Heng

AU - Chen, Jyh Hong

AU - Wu, Hua Lin

AU - Shi, Guey Yueh

AU - Tsai, Wei Chuan

AU - Chen, Pin Shern

AU - Liu, Ping Yen

N1 - Funding Information: This study was supported by the MOE Program, Tainan, Taiwan, for Promoting Academic Excellent of Universities under grant number 91-B-FA09-2-4 and by the National Science Council, Executive Yuan, Taipei, Taiwan, under grant numbers NSC-89-2314-B-006-029 and NSC-89-2314-B-006-172.

PY - 2004/1/15

Y1 - 2004/1/15

N2 - Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.

AB - Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.

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JO - American Journal of Cardiology

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ER -

Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

Abstract

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