Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

Ting-Hsing Chao, Yi-Heng Li, Jyh Hong Chen, Hua-Lin Wu, Guey Yueh Shi, Wei-Chuan Tsai, Pin Shern Chen, Ping-Yen Liu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalAmerican Journal of Cardiology
Volume93
Issue number2
DOIs
Publication statusPublished - 2004 Jan 15

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Thrombomodulin
Myocardial Infarction
Genes
Mutation
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age",
abstract = "Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.",
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Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age. / Chao, Ting-Hsing; Li, Yi-Heng; Chen, Jyh Hong; Wu, Hua-Lin; Shi, Guey Yueh; Tsai, Wei-Chuan; Chen, Pin Shern; Liu, Ping-Yen.

In: American Journal of Cardiology, Vol. 93, No. 2, 15.01.2004, p. 204-207.

Research output: Contribution to journalArticle

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T1 - Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

AU - Chao, Ting-Hsing

AU - Li, Yi-Heng

AU - Chen, Jyh Hong

AU - Wu, Hua-Lin

AU - Shi, Guey Yueh

AU - Tsai, Wei-Chuan

AU - Chen, Pin Shern

AU - Liu, Ping-Yen

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