Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Tian Jong Chang, Cai Mei Zheng, Mei Yi Wu, Tzu Ting Chen, Yun Chun Wu, Yi Lien Wu, Hsin Ting Lin, Jing Quan Zheng, Nain Feng Chu, Yu Me Lin, Sui Lung Su, Kuo Cheng Lu, Jin Shuen Chen, Fung Chang Sung, Chien Te Lee, Yu Yang, Shang Jyh Hwang, Ming-Cheng Wang, Yung Ho Hsu, Hung Yi ChiouSenyeong Kao, Yuh Feng Lin

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Abstract

This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.

Original languageEnglish
Article number6908
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Chronic Renal Insufficiency
Body Mass Index
Kidney
Population
Thinness
National Health Programs
Longitudinal Studies
Disease Progression
Comorbidity
Diabetes Mellitus
Epidemiology
Cohort Studies
Obesity
Body Weight
Databases
Hypertension

All Science Journal Classification (ASJC) codes

  • General

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Chang, Tian Jong ; Zheng, Cai Mei ; Wu, Mei Yi ; Chen, Tzu Ting ; Wu, Yun Chun ; Wu, Yi Lien ; Lin, Hsin Ting ; Zheng, Jing Quan ; Chu, Nain Feng ; Lin, Yu Me ; Su, Sui Lung ; Lu, Kuo Cheng ; Chen, Jin Shuen ; Sung, Fung Chang ; Lee, Chien Te ; Yang, Yu ; Hwang, Shang Jyh ; Wang, Ming-Cheng ; Hsu, Yung Ho ; Chiou, Hung Yi ; Kao, Senyeong ; Lin, Yuh Feng. / Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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abstract = "This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.",
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Chang, TJ, Zheng, CM, Wu, MY, Chen, TT, Wu, YC, Wu, YL, Lin, HT, Zheng, JQ, Chu, NF, Lin, YM, Su, SL, Lu, KC, Chen, JS, Sung, FC, Lee, CT, Yang, Y, Hwang, SJ, Wang, M-C, Hsu, YH, Chiou, HY, Kao, S & Lin, YF 2018, 'Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population', Scientific reports, vol. 8, no. 1, 6908. https://doi.org/10.1038/s41598-018-24757-6

Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population. / Chang, Tian Jong; Zheng, Cai Mei; Wu, Mei Yi; Chen, Tzu Ting; Wu, Yun Chun; Wu, Yi Lien; Lin, Hsin Ting; Zheng, Jing Quan; Chu, Nain Feng; Lin, Yu Me; Su, Sui Lung; Lu, Kuo Cheng; Chen, Jin Shuen; Sung, Fung Chang; Lee, Chien Te; Yang, Yu; Hwang, Shang Jyh; Wang, Ming-Cheng; Hsu, Yung Ho; Chiou, Hung Yi; Kao, Senyeong; Lin, Yuh Feng.

In: Scientific reports, Vol. 8, No. 1, 6908, 01.12.2018.

Research output: Contribution to journalArticle

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AU - Chang, Tian Jong

AU - Zheng, Cai Mei

AU - Wu, Mei Yi

AU - Chen, Tzu Ting

AU - Wu, Yun Chun

AU - Wu, Yi Lien

AU - Lin, Hsin Ting

AU - Zheng, Jing Quan

AU - Chu, Nain Feng

AU - Lin, Yu Me

AU - Su, Sui Lung

AU - Lu, Kuo Cheng

AU - Chen, Jin Shuen

AU - Sung, Fung Chang

AU - Lee, Chien Te

AU - Yang, Yu

AU - Hwang, Shang Jyh

AU - Wang, Ming-Cheng

AU - Hsu, Yung Ho

AU - Chiou, Hung Yi

AU - Kao, Senyeong

AU - Lin, Yuh Feng

PY - 2018/12/1

Y1 - 2018/12/1

N2 - This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.

AB - This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.

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