TY - JOUR
T1 - Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats
AU - Yang, Cheryl C.H.
AU - Shaw, Fu Zen
AU - Lai, Ching J.
AU - Lai, Chi Wan
AU - Kuo, Terry B.J.
N1 - Funding Information:
We thank Ms S.T. Liu and S.F. Kuo for their excellent technical support. This study was supported by the National Science Council (Taiwan) through grants NSC-89-2745-P-320-001 and NSC-89-2320-B-320-026.
PY - 2003/1/9
Y1 - 2003/1/9
N2 - To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.
AB - To explore whether depth of sleep is related to changes in autonomic control in rats, continuous power-spectral analysis of electroencephalogram (EEG) and heart rate variability (HRV) was performed in unanesthetized rats during normal daytime sleep. Quiet sleep (QS) was associated with an increase in high-frequency power of HRV (0.6-2.4 Hz, HF) but a decrease in low-frequency power (0.06-0.6 Hz) to HF ratio (LF/HF) compared with awakening. During QS, LF/HF was significantly and negatively correlated with delta power of EEG (0.5-4.0 Hz), whereas mean R-R interval and HF were not. As in humans, cardiac sympathetic regulation in rats is negatively related to the depth of sleep during QS, although vagal regulation is not. Our methodology offers a parallel way of studying the interaction between cerebral cortical and autonomic functions in rats.
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U2 - 10.1016/S0304-3940(02)01200-4
DO - 10.1016/S0304-3940(02)01200-4
M3 - Article
C2 - 12493593
AN - SCOPUS:0037426711
SN - 0304-3940
VL - 336
SP - 21
EP - 24
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -