TY - JOUR
T1 - Relationship between striatal dopamine transporter availability and sleep quality in healthy adults
AU - Chiu, Nan Tsing
AU - Lee, Bi Fang
AU - Yeh, Tzung Lieh
AU - Chen, Po See
AU - Lee, I. Hui
AU - Chen, Kao Chin
AU - Yang, Yen Kuang
N1 - Funding Information:
Acknowledgments. This study was partly supported by grants from the National Science Council of Taiwan (NSC 93-2314-B-006-017, NSC-95-2314-B-006-115-MY2, and NSC-97-2314-B-06-006-MY3) and the Atomic Energy Council of Taiwan (NSC-93-NU-7-006-004 and NSC 97-NU-7-006-001). The authors also wish to thank Ms. Ching Lin Chu, Ms. Tsai Hua Chang, Ms. Yun-Hsuan Chang, and Mr. Chien Ting Lin.
PY - 2011/12
Y1 - 2011/12
N2 - Purpose: Our previous study using 123I-iodo-benzamide single photon emission computed tomography (SPECT) showed a positive relationship in healthy adults between striatal postsynaptic D 2/D 3 receptor availability and sleep duration in good sleepers. To further investigate the role of dopamine (DA) in the sleep-wake cycle, we explored the correlation between presynaptic dopamine transporter (DAT) availability and sleep quality in healthy volunteers. Methods: A total of 83 healthy volunteers (33 males, 50 females; mean age, 34.62 years), including 39 good sleepers and 44 poor sleepers, were recruited. The sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Striatal DAT availability was determined by 99mTc-TRODAT-1 SPECT, and the DAT availability in the good and poor sleepers was compared. Furthermore, the correlation between PSQI and DAT availability was analyzed. Results: There was no significant difference in DAT availability between the good and poor sleepers. No significant relationship was found between the global score or individualcomponent PSQI scores and DAT availability in the good sleepers. However, the sleep duration component score in the poor sleepers negatively correlated with DAT availability in the caudate (ρ=-0.31, P=0.049). Conclusions: The study demonstrates that healthy poor sleepers, with a lower DAT availability in the caudate, sleep for a shorter length of time. This suggests that a decrease in DA reuptake due to reduced DAT availability causes a shorter sleep duration in poor sleepers.
AB - Purpose: Our previous study using 123I-iodo-benzamide single photon emission computed tomography (SPECT) showed a positive relationship in healthy adults between striatal postsynaptic D 2/D 3 receptor availability and sleep duration in good sleepers. To further investigate the role of dopamine (DA) in the sleep-wake cycle, we explored the correlation between presynaptic dopamine transporter (DAT) availability and sleep quality in healthy volunteers. Methods: A total of 83 healthy volunteers (33 males, 50 females; mean age, 34.62 years), including 39 good sleepers and 44 poor sleepers, were recruited. The sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Striatal DAT availability was determined by 99mTc-TRODAT-1 SPECT, and the DAT availability in the good and poor sleepers was compared. Furthermore, the correlation between PSQI and DAT availability was analyzed. Results: There was no significant difference in DAT availability between the good and poor sleepers. No significant relationship was found between the global score or individualcomponent PSQI scores and DAT availability in the good sleepers. However, the sleep duration component score in the poor sleepers negatively correlated with DAT availability in the caudate (ρ=-0.31, P=0.049). Conclusions: The study demonstrates that healthy poor sleepers, with a lower DAT availability in the caudate, sleep for a shorter length of time. This suggests that a decrease in DA reuptake due to reduced DAT availability causes a shorter sleep duration in poor sleepers.
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U2 - 10.1007/s11307-010-0442-6
DO - 10.1007/s11307-010-0442-6
M3 - Article
C2 - 20953736
AN - SCOPUS:84855661971
SN - 1536-1632
VL - 13
SP - 1267
EP - 1271
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 6
ER -