Reliability analysis of physiological phenomena by cardiac action potential model

To simulate ventricular cardiac action potentials used Luo-Rudy phase I cell model with hybrid method, the computation time can be 100 times faster than RK4 (fixed step 0.01); However, the hybrid method of time step 0.8-2.0 causes the irregular S:R ratio by Wenckebach periodicity as stimulation 30 beats; other hybrid methods can adequately simulate cardiac physiology phenomena and prevent from phantom simulation. In this study, we analysis the simulation reliability and accuracy for three different speeds of hybrid methods that compare to RK4 (0.01), thus a suggestion can be understood how to select the right methods to simulate the physiological phenomena under computing speed fast enough and maintain the accuracy, saving huge amount of the computing time in the cardiac simulations.