TY - JOUR
T1 - Remodeling of calcium signaling in tumor progression
AU - Chen, Yih Fung
AU - Chen, Ying Ting
AU - Chiu, Wen Tai
AU - Shen, Meng Ru
N1 - Funding Information:
This work was partly supported by National Science Council, National Health Research Institutes, Department of Health, Executive Yuan and National Cheng Kung University Hospital, Taiwan.
PY - 2013
Y1 - 2013
N2 - Intracellular Ca§ssup§2+§esup§ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca§ssup§2+§esup§ homeostasis has been suggested as an important event in driving the expression of the malignant phenotypes, such as proliferation, migration, invasion, and metastasis. Cell migration is an early prerequisite for tumor metastasis that has a significant impact on patient prognosis. During cell migration, the exquisite spatial and temporal organization of intracellular Ca§ssup§2+§esup§ provides a rapid and robust way for the selective activation of signaling components that play a central role in cytoskeletal reorganization, traction force generation, and focal adhesion dynamics. A number of known molecular components involved in Ca§ssup§2+§esup§ influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca§ssup§ 2+§esup§ entry (SOCE) and the Ca§ssup§2+§esup§- permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. The clinical significance of these molecules, such as STIM proteins and the TRPM7 channel, in tumor progression and their diagnostic and prognostic potentials have also been demonstrated in specific cancer types. In this review, we summarize the recent advances in understanding the important roles and regulatory mechanisms of these Ca§ssup§2+§esup§ influx pathways on malignant behaviors of tumor cells. The clinical implications in facilitating current diagnostic and therapeutic procedures are also discussed.
AB - Intracellular Ca§ssup§2+§esup§ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca§ssup§2+§esup§ homeostasis has been suggested as an important event in driving the expression of the malignant phenotypes, such as proliferation, migration, invasion, and metastasis. Cell migration is an early prerequisite for tumor metastasis that has a significant impact on patient prognosis. During cell migration, the exquisite spatial and temporal organization of intracellular Ca§ssup§2+§esup§ provides a rapid and robust way for the selective activation of signaling components that play a central role in cytoskeletal reorganization, traction force generation, and focal adhesion dynamics. A number of known molecular components involved in Ca§ssup§2+§esup§ influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca§ssup§ 2+§esup§ entry (SOCE) and the Ca§ssup§2+§esup§- permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. The clinical significance of these molecules, such as STIM proteins and the TRPM7 channel, in tumor progression and their diagnostic and prognostic potentials have also been demonstrated in specific cancer types. In this review, we summarize the recent advances in understanding the important roles and regulatory mechanisms of these Ca§ssup§2+§esup§ influx pathways on malignant behaviors of tumor cells. The clinical implications in facilitating current diagnostic and therapeutic procedures are also discussed.
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U2 - 10.1186/1423-0127-20-23
DO - 10.1186/1423-0127-20-23
M3 - Review article
C2 - 23594099
AN - SCOPUS:84876098016
VL - 20
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
SN - 1021-7770
IS - 1
M1 - 23
ER -