Removal of diphenhydramine from water by swelling clay minerals

Zhaohui Li, Po Hsiang Chang, Wei Teh Jiang, Jiin Shuh Jean, Hanlie Hong, Libing Liao

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Frequent detection of pharmaceuticals in surface water and wastewater attracted renewed attention on studying interactions between pharmaceuticals and sludge or biosolids generated from wastewater treatment. Less attention was focused on studying interactions between pharmaceuticals and clay minerals, important soil and sediment components. This research targeted on investigating interactions between diphenhydramine (DPH), an important antihistamine drug, and a montmorillonite, a swelling clay, in aqueous solution. Stoichiometric desorption of exchangeable cations accompanying DPH adsorption confirmed that cation exchange was the most important mechanism of DPH uptake by the swelling clay. When the solution pH was below the pKa of DPH, its adsorption on the swelling clay was less affected by pH. Increasing solution pH above the pKa value resulted in a decrease in DPH adsorption by the clay. An increase in d001 spacing at a high DPH loading level suggested interlayer adsorption, thus, intercalation of DPH. The results from this study showed that swelling clays are a good environmental sink for weak acidic drugs like DPH. In addition, the large cation exchange capacity and surface area make the clay a good candidate to remove cationic pharmaceuticals from the effluent of wastewater treatment facilities.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalJournal of Colloid And Interface Science
Issue number1
Publication statusPublished - 2011 Aug 1

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry


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