Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

I. Kuan Wang, Chung Hsiang Liu, Tzung Hai Yen, Jiann Shing Jeng, Sheng Feng Sung, Pai Hao Huang, Jie Yuan Li, Yu Sun, Cheng Yu Wei, Li Ming Lien, I. Ju Tsai, Fung Chang Sung, Chung Y. Hsu, Chung Hsiang Liu, Chon Haw Tsai, Wei Shih Huang, Chung Ta Lu, Tzung Chang Tsai, Chun Hung Tseng, Kang Hsu LinWoei Cherng Shyu, Yu Wan Yang, Yen Liang Liu, Der Yang Cho, Chun Chung Chen, Sung Chun Tang, Li Kai Tsai, Shin Joe Yeh, Chih Hao Chen, Hsin Hsi Tsai, Han Jung Chen, Kan Lu, Shih Pin Hsu, Hung Chang Kuo, Jung Chi Tsou, Yan Tang Wang, Yi Cheng Tai, Meng Tsang Hsieh, Po Chao Liliang, Cheng Loong Liang, Hao Kuang Wang, Yu Tun Tsai, Kuo Wei Wang, Jui Sheng Chen, Po Yuan Chen, Yi Ching Wang, Pi Shan Sung, Han Chieh Hsieh, Hui Chen Su, Hou Chang Chiu, Wei Hung Chen, Chyi Huey Bai, Tzu Hsuan Huang, Chi Ieong Lau, Ya Ying Wu, Hsu Ling Yeh, Anna Chang, Ching Huang Lin, Cheng Chang Yen, Ruey Tay Lin, Gim Thean Khor, A. Ching Chao, Hsiu Fen Lin, Poyin Huang, Huey Juan Lin, Der Shin Ke, Chia Yu Chang, Poh Shiow Yeh, Kao Chang Lin, Tain Junn Cheng, Chih Ho Chou, Chun Ming Yang, Hsiu Chu Shen, An Chih Chen, Shih Jei Tsai, Tsong Ming Lu, Sheng Ling Kung, Mei Ju Lee, Hsi Hsien Chou, Wei Lun Chang, Pai Yi Chiu, Min Hsien Hsu, Po Chi Chan, Chau Hsiung Pan, Hai Ming Shoung, Yi Chen Lo, Fu Hwa Wang, Wei Chieh Chang, Ta Chang Lai, Jiu Haw Yin, Chung Jen Wang, Kai Chen Wang, Li Mei Chen, Jong Chyou Denq, Chien Jung Lu, Chieh Cheng Huang, Hoi Fong Chan, Siu Pak Lee, Ming Hui Sun, Li Ying Ke, Po Lin Chen, Yu Shan Lee, Cheung Ter Ong, Chi Shun Wu, Yung Chu Hsu, Yu Hsiang Su, Ling Chien Hung, Jiunn Tay Lee, Jiann Chyun Lin, Yaw Don Hsu, Giia Sheun Peng, Chang Hung Hsu, Chun Chieh Lin, Che Hung Yen, Chun An Cheng, Yueh Feng Sung, Yuan Liang Chen, Ming Tung Lien, Chia Chen Liu, Fu Chi Yang, Yi Chung Wu, An Chen Tso, Yu Hua Lai, Chun I. Chiang, Chia Kuang Tsai, Meng Ta Liu, Ying Che Lin, Tsuey Ru Chiang, Pin Wen Liao, Mei Ching Lee, Jen Tse Chen, Sian King Lie, Mu Chien Sun, Pi Ju Hsiao, Wei Liang Chen, Ta Cheng Chen, Chen Shu Chang, Chien Hsu Lai, Chieh Sen Chuang, Yen Yu Chen, Shinn Kuang Lin, Yu Chin Su, Jen Lun Shiao, Fu Yi Yang, Chih Yang Liu, Han Lin Chiang, Guei Chiuan Chen, Po Jen Hsu, I. sheng Lin, Chung Hsien Chien, Yang Chuang Chang, Ping Kun Chen, Yu Jen Hsiao, Chen Wen Fang, Yu Wei Chen, Kuo Ying Lee, Yun Yu Lin, Chen Hua Li, Hui Fen Tsai, Chuan Fa Hsieh, Chih Dong Yang, Shiumn Jen Liaw, How Chin Liao, Ling Li Wu, Liang Po Hsieh, Yong Hui Lee, Chung Wen Chen, Chih Shan Hsu, Ye Jian Jhih, Hao Yu Zhuang, Yan Hong Pan, Shin An Shih, Chin I. Chen, Jia Ying Sung, Hsing Yu Weng, Hao Wen Teng, Jing Er Lee, Chih Shan Huang, Shu Ping Chao, Rey Yue Yuan, Jau Jiuan Sheu, Jia Ming Yu, Chun Sum Ho, Ting Chun Lin, Shih Chieh Yu, Jiunn Rong Chen, Song Yen Tsai, Cheng Yu Wei, Chao Hsien Hung, Chia Fang Lee, Sheng Kung Yang, Chih Lin Chen, Wei Lin, Hung Pin Tseng, Chun Liang Lin, Hung Chih Lin, Pi Tzu Chen, Chaur Jong Hu, Lung Chan, Nai Fang Chi, Chang Ming Chern, Chun Jen Lin, Shuu Jiun Wang, Li Chi Hsu, Wen Jang Wong, I. Hui Lee, Der Jen Yen, Ching Piao Tsai, Shang Yeong Kwan, Bing Wen Soong, Shih Pin Chen, Kwong Kum Liao, Kung Ping Lin, Chien Chen, Din E. Shan, Jong Ling Fuh, Pei Ning Wang, Yi Chung Lee, Yu Hsiang Yu, Hui Chi Huang, Jui Yao Tsai, Ming Hsiu Wu, Szu Yi Chiang, Chiung Yao Wang, Ming Chin Hsu, Po Yen Yeh, Ko Yi Wang, Tsang Shan Chen, Cheng Yang Hsieh, Wei Fen Chen, Ping Keung Yip, Vinchi Wang, Chung Fen Tsai, Chao Ching Chen, Yi Chien Liu, Shao Yuan Chen, Zi Hao Zhao, Zhi Peng Wei, Shey Lin Wu, Ching Kuan Liu, Ryh Huei Lin, Ching Hua Chu, Sui Hing Yan, Sheng Huang Hsiao, Bak Sau Yip, Pei Chun Tsai, Ping Chen Chou, Tsam Ming Kuo, Yi Pin Chiu, Kun Chang Tsai, Yi Sheng Liao, Ming Jun Tsai, Hsin Yi Kao

Research output: Contribution to journalArticle

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Abstract

Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

Original languageEnglish
Pages (from-to)288-293
Number of pages6
JournalAtherosclerosis
Volume269
DOIs
Publication statusPublished - 2018 Feb 1

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Wang, I. K., Liu, C. H., Yen, T. H., Jeng, J. S., Sung, S. F., Huang, P. H., Li, J. Y., Sun, Y., Wei, C. Y., Lien, L. M., Tsai, I. J., Sung, F. C., Hsu, C. Y., Liu, C. H., Tsai, C. H., Huang, W. S., Lu, C. T., Tsai, T. C., Tseng, C. H., ... Kao, H. Y. (2018). Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis, 269, 288-293. https://doi.org/10.1016/j.atherosclerosis.2017.11.029