TY - JOUR
T1 - Reprint of "Review of Dscam-mediated immunity in shrimp and other arthropods"
AU - Ng, Tze Hann
AU - Chiang, Yi An
AU - Yeh, Ying Chun
AU - Wang, Han Ching
N1 - Funding Information:
We appreciate Dr. Irene Söderhäll for her kind invitation to contribute this review article. This investigation was supported financially by the National Science Council ( NSC 101-2324-B-006-001-CC1 and NSC 101-2628-B-006-001-MY4 ). We are indebted to Paul Barlow for his helpful criticism.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Although true adaptive immunity is only found in vertebrates, there is increasing evidence that shrimp and other arthropods exhibit immune specificity and immune memory. The invertebrate immune response is now called "innate immunity with specificity" or "immune priming", and its underlying mechanisms are still unclear. However, while vertebrate antibodies have no invertebrate homolog, the Down syndrome cell adhesion molecule (Dscam), which is a hypervariable protein created by alternative splicing, can function as a pathogen-specific recognizing molecule in arthropods. Here we review our current understanding of the Dscam-mediated immune responses in arthropods, especially in shrimp, and show that Dscam may be involved in both general innate immunity and the pathogen-specific immune response.
AB - Although true adaptive immunity is only found in vertebrates, there is increasing evidence that shrimp and other arthropods exhibit immune specificity and immune memory. The invertebrate immune response is now called "innate immunity with specificity" or "immune priming", and its underlying mechanisms are still unclear. However, while vertebrate antibodies have no invertebrate homolog, the Down syndrome cell adhesion molecule (Dscam), which is a hypervariable protein created by alternative splicing, can function as a pathogen-specific recognizing molecule in arthropods. Here we review our current understanding of the Dscam-mediated immune responses in arthropods, especially in shrimp, and show that Dscam may be involved in both general innate immunity and the pathogen-specific immune response.
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U2 - 10.1016/j.dci.2014.07.017
DO - 10.1016/j.dci.2014.07.017
M3 - Review article
AN - SCOPUS:85027957159
VL - 48
SP - 306
EP - 314
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
SN - 0145-305X
IS - 2
ER -