Responses of microglia and neural progenitors to mechanical brain injury

Shun Fen Tzeng, Jen Pey Wu

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

NEURAL cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infiltration along with nuclear factor kappa B (NFκB)/p65 activation at the lesion site. Most NFκB/p65+ cells displayed a phagocytic morphology. Under these conditions, profound cell apoptosis took place in the injured corpus callosum, but not in the subventricular/ventricular zone (SVZ/VZ). The SVZ/VZ-derived neural progenitors in both injected and non-injected contralateral hemispheres showed strong BrdU immunostaining, indicating that SVZ/VZ-derived neural progenitors of both hemispheres may undergo DNA synthesis in response to unilateral brain injury.

Original languageEnglish
Pages (from-to)2287-2292
Number of pages6
JournalNeuroReport
Volume10
Issue number11
DOIs
Publication statusPublished - 1999 Aug 2

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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