Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

Yuh Feng Lin, Yu Hsuan Lee, Yung Ho Hsu, Yi Jie Chen, Yuan Feng Lin, Fong Yu Cheng, Hui Wen Chiu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.

Original languageEnglish
Pages (from-to)2741-2756
Number of pages16
JournalNanomedicine
Volume12
Issue number22
DOIs
Publication statusPublished - 2017 Nov

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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