Review of Dscam-mediated immunity in shrimp and other arthropods

Tze Hann Ng, Yi An Chiang, Ying Chun Yeh, Han Ching Wang

Research output: Contribution to journalReview articlepeer-review

46 Citations (Scopus)

Abstract

Although true adaptive immunity is only found in vertebrates, there is increasing evidence that shrimp and other arthropods exhibit immune specificity and immune memory. The invertebrate immune response is now called "innate immunity with specificity" or "immune priming", and its underlying mechanisms are still unclear. However, while vertebrate antibodies have no invertebrate homolog, the Down syndrome cell adhesion molecule (Dscam), which is a hypervariable protein created by alternative splicing, can function as a pathogen-specific recognizing molecule in arthropods. Here we review our current understanding of the Dscam-mediated immune responses in arthropods, especially in shrimp, and show that Dscam may be involved in both general innate immunity and the pathogen-specific immune response.

Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalDevelopmental and Comparative Immunology
Volume46
Issue number2
DOIs
Publication statusPublished - 2014 Oct

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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