Review: Roles of microenvironment and mechanical forces in cell and tissue remodeling

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

This article provides a brief review of current research in cellular and tissue biomechanics, with an emphasis on the roles of the extracellular matrix and external forces on cell and tissue remodeling. In this rapidly developing interdisciplinary field, molecular biology, biochemistry, material science, biomedical engineering, and clinical medicine are integrated to understand intracellular signal transduction, gene regulation, tissue remodeling, and functional restoration or regeneration of injured or degenerated tissues and organs. Analysis of the responses to various types of externally applied force over a range of magnitude scales has helped to elucidate how cells sense external forces and respond to microenvironments from the single cell to tissue levels, from the micro to marco scales, and from two dimensions to three dimensions.

Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalJournal of Medical and Biological Engineering
Volume31
Issue number4
DOIs
Publication statusPublished - 2011 Oct 3

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Tissue
Biomedical Engineering
Cellular Microenvironment
Signal transduction
Biochemistry
Molecular biology
Biomedical engineering
Biomechanics
Clinical Medicine
Materials science
Biomechanical Phenomena
Gene expression
Restoration
Medicine
Extracellular Matrix
Regeneration
Molecular Biology
Signal Transduction
Research
Genes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

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Review : Roles of microenvironment and mechanical forces in cell and tissue remodeling. / Su, Fong Chin; Wu, Chia Ching; Chien, Shu.

In: Journal of Medical and Biological Engineering, Vol. 31, No. 4, 03.10.2011, p. 233-244.

Research output: Contribution to journalReview article

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